Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis

Autor:	Carolyn Deloa, Bruce C.A. Cree, Lisa F. Barcellos, Giovanni Savettieri, Antonio Uccelli, Stephen Sawcer, Jorge R. Oksenberg, Farren B.S. Briggs, Xavier Montalban, Patricia P. Ramsay, Margaret A. Pericak-Vance, Glenys Thomson, Pablo Villoslada, Ann B. Begovich, Robin R. Lincoln, Stephen L. Hauser, Jonathan L. Haines, Sergio E. Baranzini, Alastair Compston
Přispěvatelé:	BARCELLOS LF, SAWCER S, RAMSAY PP, BARANZINI SE, THOMSON G, BRIGGS F, CREE BC, BEGOVICH AB, VILLOSLADA P, MONTALBAN X, UCCELLI A, SAVETTIERI G, LINCOLN RR, DELOA C, HAINES JL, PERICAK-VANCE MA, COMPSTON A, HAUSER SL, OKSENBERG JR
Jazyk:	angličtina
Rok vydání:	2006
Předmět:	Models Molecular Male Sequence Homology immune system diseases Models Risk Factors Databases Genetic Adult Alleles Amino Acid Sequence Databases Genetic Female Genetic Variation Genotype HLA-DR Antigens chemistry/genetics HLA-DRB1 Chains Humans Male Middle Aged Models Molecular Molecular Sequence Data Multiple Sclerosis Chronic Progressive genetics/immunology Multiple Sclerosis genetics/immunology Phenotype Risk Factors Sequence Homology Amino Acid skin and connective tissue diseases HLA-DRB1 Genetics (clinical) Genetics General Medicine Multiple Sclerosis Chronic Progressive Middle Aged Phenotype Female musculoskeletal diseases Adult Multiple Sclerosis Genotype Molecular Sequence Data Locus (genetics) Human leukocyte antigen Biology Databases Alleles phenotype heterogeneity human leukocyte antigens age of onset chromosomes genes genotype haplotypes multiple sclerosis relapsing-remitting genetics disability primary progressive multiple sclerosis hla-drb1 gene illness length severity of illness Genetic Genetic variation medicine Humans Amino Acid Sequence Allele Molecular Biology Alleles Sequence Homology Amino Acid Multiple sclerosis Haplotype Genetic Variation Molecular HLA-DR Antigens medicine.disease genetics/immunology chemistry/genetics Immunology Age of onset HLA-DRB1 Chains
Popis:	Variation in major histocompatibility complex genes on chromosome 6p21.3, specifically the human leukocyte antigen HLA-DR2 or DRB1*1501-DQB1*0602 extended haplotype, confers risk for multiple sclerosis (MS). Previous studies of DRB1 variation and both MS susceptibility and phenotypic expression have lacked statistical power to detect modest genotypic influences, and have demonstrated conflicting results. Results derived from analyses of 1339 MS families indicate DRB1 variation influences MS susceptibility in a complex manner. DRB1*15 was strongly associated in families (P=7.8x10(-31)), and a dominant DRB1*15 dose effect was confirmed (OR=7.5, 95% CI=4.4-13.0, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5073f47dc8cd420790896b04d9fc41 http://hdl.handle.net/11567/332938 Zobrazit plný text záznamu