Lack of phospholipase C-delta1 induces skin inflammation
| Autor: | Yoshikazu Nakamura, Kentaro Sai, Kiyoko Fukami, Masamichi Nakahara, Hideki Yamaguchi, Manabu Ichinohe |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Erythema medicine.medical_treatment Biophysics Inflammation Biology Biochemistry Mice Immune system Internal medicine medicine Animals Immunologic Factors Molecular Biology Skin Mice Knockout integumentary system Phospholipase C Cell Biology Hair follicle medicine.disease Immunity Innate Isoenzymes Endocrinology medicine.anatomical_structure Hair loss Cytokine Type C Phospholipases Cytokines medicine.symptom Phospholipase C delta Homeostasis |
| Zdroj: | Biochemical and biophysical research communications. 356(4) |
| ISSN: | 0006-291X |
| Popis: | Phospholipase C (PLC) is a key enzyme in phosphoinositide signaling. We previously generated PLC-delta1 knockout (KO) mice and found that these mice showed remarkable hair loss caused by abnormalities in hair follicle structures. Here we show that the skin of PLC-delta1 KO mice displays typical inflammatory phenotypes, including increased dermal cellularity, leukocyte infiltration, and expression of pro-inflammatory cytokines. In addition, exogenously expressed PLC-delta1 attenuates lipopolysaccharide-induced expression of IL-1beta, a pro-inflammatory cytokine, in an enzymatic activity-dependent manner. Furthermore, suppression of skin inflammation by anti-inflammatory reagents cured the epidermal hyperplasia in PLC-delta1 KO mice. Taken together, these results indicate that lack of PLC-delta1 induces skin inflammation and that the epidermal hyperplasia in PLC-delta1 KO mice is caused by skin inflammation. Our results also suggest that PLC-delta1 regulates homeostasis of the immune system in skin. |
| Databáze: | OpenAIRE |
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