A novel aspochalasin with HIV-1 integrase inhibitory activity from Aspergillus flavipes

Autor:	Samantha George, Joanne Ford, Simone Rochfort, Barbara M. Meurer-Grimes, Soo San Wan, R. Murray Tait, Simon P. B. Ovenden, Jonathan Coates, Howard G. Wildman, David Ian Rhodes, Susan Cox
Rok vydání:	2005
Předmět:	Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy Chemical Phenomena Spectrophotometry Infrared Molecular Conformation Biology ASPERGILLUS FLAVIPES Microbiology Drug Discovery Spectroscopy Fourier Transform Infrared HIV Integrase Inhibitors Fermentation broth IC50 Pharmacology Chemistry Physical Aspochalasin L Virology Cytochalasins Integrase Culture Media Aspergillus Fermentation biology.protein Hiv 1 integrase HIV-1 Spectrophotometry Ultraviolet
Zdroj:	Scopus-Elsevier
ISSN:	0021-8820
Popis:	A novel aspochalasin, aspochalasin L (1), was isolated from the fermentation broth of a soil-derived fungal culture identified as Aspergillus flavipes (Deuteromycota). Structure elucidation of 1 was accomplished by detailed spectroscopic data analyses and by comparison with related cytochalasins. Aspochalasin L demonstrated activity against HIV integrase with an IC50 of 71.7microM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4b69ded485cee5e77e74d8767fbc3b https://pubmed.ncbi.nlm.nih.gov/15981416 Zobrazit plný text záznamu