| Autor: |
Robert Thänert, JooHee Choi, Kimberly A. Reske, Tiffany Hink, Anna Thänert, Meghan A. Wallace, Bin Wang, Sondra Seiler, Candice Cass, Margaret H. Bost, Emily L. Struttmann, Zainab Hassan Iqbal, Steven R. Sax, Victoria J. Fraser, Arthur W. Baker, Katherine R. Foy, Brett Williams, Ben Xu, Pam Capocci-Tolomeo, Ebbing Lautenbach, Carey-Ann D. Burnham, Erik R. Dubberke, Jennie H. Kwon, Gautam Dantas |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cell Host & Microbe. 30:1034-1047.e6 |
| ISSN: |
1931-3128 |
| DOI: |
10.1016/j.chom.2022.04.008 |
| Popis: |
Large-scale genomic studies have identified within-host adaptation as a hallmark of bacterial infections. However, the impact of physiological, metabolic, and immunological differences between distinct niches on the pathoadaptation of opportunistic pathogens remains elusive. Here, we profile the within-host adaptation and evolutionary trajectories of 976 isolates representing 119 lineages of uropathogenic Escherichia coli (UPEC) sampled longitudinally from both the gastrointestinal and urinary tracts of 123 patients with urinary tract infections. We show that lineages persisting in both niches within a patient exhibit increased allelic diversity. Habitat-specific selection results in niche-specific adaptive mutations and genes, putatively mediating fitness in either environment. Within-lineage inter-habitat genomic plasticity mediated by mobile genetic elements (MGEs) provides the opportunistic pathogen with a mechanism to adapt to the physiological conditions of either habitat, and reduced MGE richness is associated with recurrence in gut-adapted UPEC lineages. Collectively, our results establish niche-specific adaptation as a driver of UPEC within-host evolution. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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