Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise
| Autor: | Glenn A. Nickele, Craig A. Harms, Thomas J. Wetter, Peter Hanson, Jerome A. Dempsey, David F. Pegelow, William Bert Nelson, Steven R. McClaran |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac output Physiology Hemodynamics Physical Therapy Sports Therapy and Rehabilitation Respiratory physiology Work of breathing Oxygen Consumption Physiology (medical) Internal medicine medicine Respiratory muscle Humans Respiratory system Exercise physiology Cardiac Output Exercise Lung Air Pressure Leg business.industry Airway Resistance Blood flow Respiratory Muscles Physical therapy Cardiology Blood Gas Analysis business |
| Zdroj: | Journal of applied physiology (Bethesda, Md. : 1985). 85(2) |
| ISSN: | 8750-7587 |
| Popis: | We have recently demonstrated that changes in the work of breathing during maximal exercise affect leg blood flow and leg vascular conductance (C. A. Harms, M. A. Babcock, S. R. McClaran, D. F. Pegelow, G. A. Nickele, W. B. Nelson, and J. A. Dempsey. J. Appl. Physiol. 82: 1573–1583, 1997). Our present study examined the effects of changes in the work of breathing on cardiac output (CO) during maximal exercise. Eight male cyclists [maximal O2 consumption (V˙o 2 max): 62 ± 5 ml ⋅ kg−1 ⋅ min−1] performed repeated 2.5-min bouts of cycle exercise atV˙o 2 max. Inspiratory muscle work was either 1) at control levels [inspiratory esophageal pressure (Pes): −27.8 ± 0.6 cmH2O], 2) reduced via a proportional-assist ventilator (Pes: −16.3 ± 0.5 cmH2O), or 3) increased via resistive loads (Pes: −35.6 ± 0.8 cmH2O). O2 contents measured in arterial and mixed venous blood were used to calculate CO via the direct Fick method. Stroke volume, CO, and pulmonary O2 consumption (V˙o 2) were not different ( P > 0.05) between control and loaded trials atV˙o 2 max but were lower (−8, −9, and −7%, respectively) than control with inspiratory muscle unloading atV˙o 2 max. The arterial-mixed venous O2difference was unchanged with unloading or loading. We combined these findings with our recent study to show that the respiratory muscle work normally expended during maximal exercise has two significant effects on the cardiovascular system: 1) up to 14–16% of the CO is directed to the respiratory muscles; and 2) local reflex vasoconstriction significantly compromises blood flow to leg locomotor muscles. |
| Databáze: | OpenAIRE |
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