Cytomegalovirus Seropositivity Is Associated With Increased Microbial Translocation in People Living With Human Immunodeficiency Virus and Uninfected Controls
| Autor: | Brandon Fombuena, Yonglong Zhang, Malcolm A. Finkelman, Jing Ouyang, Guy Boivin, Rayoun Ramendra, Vikram Mehraj, Petronela Ancuta, Carl Chartrand-Lefebvre, Madeleine Durand, Jean-Pierre Routy, Cécile Tremblay, Bertrand Lebouché, Cecilia T. Costiniuk, Stéphane Isnard, John Lin |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Immunoglobulin A microbial translocation Congenital cytomegalovirus infection Cytomegalovirus HIV Infections Antibodies Viral Systemic inflammation Immunoglobulin G Virus Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine Articles and Commentaries Aged biology Coinfection business.industry virus diseases HIV medicine.disease 3. Good health AcademicSubjects/MED00290 030104 developmental biology Infectious Diseases inflammation Immunoglobulin M Cytomegalovirus Infections Immunology biology.protein epithelial gut damage medicine.symptom business |
| Zdroj: | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/ciz1001 |
| Popis: | Background Cytomegalovirus (CMV) seropositivity and anti-CMV immunoglobulin G (IgG) levels are associated with adverse health outcomes in elderly populations. Among people living with human immunodeficiency virus (PLWH), CMV seropositivity has been associated with persistent CD8 T-cell elevation and increased risk of developing non-AIDS comorbidities despite long-term antiretroviral therapy (ART). Herein, we investigated whether CMV seropositivity and elevation of anti-CMV IgG levels were associated with increased epithelial gut damage, microbial translocation, and systemic inflammation. Methods A total of 150 PLWH (79 ART-naive and 71 ART-treated) were compared to 26 without human immunodeficiency virus (HIV) infection (uninfected controls). Plasma markers of HIV disease progression, epithelial gut damage, microbial translocation, nonspecific B-cell activation, anti-CMV and anti–Epstein-Barr virus (EBV) IgG levels, and proinflammatory cytokines were measured. Results CMV seropositivity and elevated anti-CMV IgG levels were associated with markers of epithelial gut damage, microbial translocation, and inflammation in PLWH and participants without HIV infection. In contrast, total nonspecific IgG, immunoglobulin M, immunoglobulin A, and anti-EBV IgG levels were not associated with these markers. CMV seropositivity was associated with markers of epithelial gut damage, microbial translocation, and inflammation independent of sociodemographic and behavioral characteristics of the study population. Conclusions CMV-seropositive people with and without HIV had increased epithelial gut damage, microbial translocation, and inflammation. Furthermore, anti-CMV IgG levels were independently associated with increased epithelial gut damage and microbial translocation. CMV coinfection may partially explain persistent gut damage, microbial translocation, and inflammation in ART-treated PLWH. Cytomegalovirus (CMV) seropositivity and anti-CMV immunoglobulin G levels are associated with increased epithelial gut damage, microbial translocation, and inflammation in antiretroviral therapy (ART)–naive and ART-treated people living with human immunodeficiency virus and uninfected controls. |
| Databáze: | OpenAIRE |
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