Can selenium levels act as a marker of colorectal cancer risk?
| Autor: | Rodney J. Scott, Mari-Liis Tammesoo, Anu Viitak, Katarzyna Durda, Magdalena Muszyńska, Grzegorz Sukiennicki, Jan Lubinski, Anders Metspalu, Martin Tootsi, Katarzyna Jaworska-Bieniek, Pablo Serrano-Fernández, Józef Kładny, Anna Jakubowska, Maria Kulp, Marcin Lener, Satish Gupta |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Estonia Cancer Research Pathology medicine.medical_specialty Antioxidant Colorectal cancer medicine.medical_treatment chemistry.chemical_element Gastroenterology 03 medical and health sciences Selenium Cancer risk Dietary supplement 0302 clinical medicine Blood serum Risk Factors Internal medicine Genetics medicine Biomarkers Tumor Odds Ratio Humans Colorectal 030304 developmental biology Aged Aged 80 and over 0303 health sciences business.industry Case-control study Odds ratio Middle Aged medicine.disease 3. Good health Exact test Oncology chemistry 030220 oncology & carcinogenesis Case-Control Studies Poland business Risk assessment Colorectal Neoplasms Research Article |
| Zdroj: | BMC Cancer |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/1471-2407-13-214 |
| Popis: | Background Selenium has attracted attention because of its antioxidant properties. Antioxidants protects cells from damage. Certain breakdown products of selenium are believed to prevent tumor growth by enhancing the immune cell activity and suppressing the development of tumor blood vessels. In this observational study, selenium level was measured in a series of patients from Poland and Estonia to determine a correlation between levels of this microelement and colorectal cancer risk. Methods A total of 169 colorectal cancer patients and 169 healthy controls were enrolled in the study after obtaining their informed consent. Selenium level in the blood serum was measured using Graphite Furnace Atomic Absorption Spectrometry (GFAAS). The statistical analysis was performed by Fisher’s exact test. Results The threshold point of selenium level was 55 μg/l and 65 μg/l for Poland and Estonia respectively, for an increase in cancer risk. The lower levels of selenium were associated with greater risk of colorectal cancer. Conclusions The result reveals a significant strong association between low selenium level and the colorectal cancer risk in both Estonian and Polish populations. |
| Databáze: | OpenAIRE |
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