The genetic polymorphisms of melanocortin-4 receptor gene are associated with carcass quality traits in a Chinese indigenous beef cattle breed
| Autor: | Gui Yao Liu, Hamed Shoorei, Li Zhou, Motahareh Amjadi, Ahmed Sabek, Ayman H. Abd El-Aziz, Linsheng Gui, Sayed Haidar Abbas Raza |
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| Rok vydání: | 2019 |
| Předmět: |
Meat
Genotype 040301 veterinary sciences Population Single-nucleotide polymorphism Beef cattle Biology Genetic analysis 0403 veterinary science 03 medical and health sciences Animals education 030304 developmental biology Genetic association Genetics 0303 health sciences education.field_of_study Polymorphism Genetic General Veterinary 04 agricultural and veterinary sciences Breed Melanocortin 4 receptor Receptor Melanocortin Type 4 Cattle Female Intramuscular fat |
| Zdroj: | Research in veterinary science. 132 |
| ISSN: | 1532-2661 |
| Popis: | Melanocortin-4 receptor (MC4R) was considered as an essential modifiers in feelings intake, the regulation of metabolism and body weight. This study aimed at identifying polymorphisms in MC4R gene that might associate with carcass quality traits in Chinese indigenous beef cattle breed. qPCR analysis showed that the MC4R gene was widely expressed in various tissues, with predominantly expression levels in heart. Three single-nucleotide polymorphisms (SNPs) were identified, including a mutation (g.85A > G) in 5’untranslated regions (UTR) and two mutations (g.927C > T and g.1069C > G) in exon 1. Based on the χ2 test, both g.927C > T and g.1069C > G loci fitted with Hardy-Weinberg equilibrium (P > .05). Population genetic analysis showed that except for g.85A > G, the other detected SNPs strongly affected the bovine back fat thickness and intramuscular fat content (P |
| Databáze: | OpenAIRE |
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