Thyroid dysfunction following combined therapy for laryngeal carcinoma
| Autor: | N. O'meara, M. J. Donnelly, T. P. O'dwyer |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Pathology endocrine system diseases medicine.medical_treatment Thyroid Gland Laryngectomy Thyroid Lobectomy Thyroid Function Tests Gastroenterology Thyroid function tests Hypothyroidism Thyroid-stimulating hormone Internal medicine Humans Medicine Laryngeal Neoplasms Aged Retrospective Studies Subclinical infection Radiotherapy medicine.diagnostic_test business.industry Carcinoma Thyroid Middle Aged Combined Modality Therapy Radiation therapy medicine.anatomical_structure Otorhinolaryngology Female Larynx Thyroid function business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Clinical Otolaryngology. 20:254-257 |
| ISSN: | 1749-4486 1749-4478 |
| DOI: | 10.1111/j.1365-2273.1995.tb01861.x |
| Popis: | The thyroid function of 27 patients who previously had carcinoma of the larynx treated by total laryngectomy with thyroid lobectomy was studied by measuring levels of thyroxine (T4) and thyroid stimulating hormone (TSH). Twenty-two of these patients also received external beam radiotherapy. Abnormal results were found in 45% (10 patients) of those who received combined therapy. Clinical hypothyroidism developed in two patients (9%) and subclinical hypothyroidism (elevated TSH) was seen in eight patients (36%). Eighty-eight per cent of those patients with subclinical hypothyroidism had low or low normal T4 levels. All the patients treated with surgery only had normal thyroid function. To prevent hypothyroidism and identify those at risk of developing hypothyroidism, post-operative testing of thyroid function should be carried out on a routine basis in patients receiving combined therapy for laryngeal cancer. In addition we recommend that patients with subclinical hypothyroidism who have had combined treatment should be treated with thyroxine to prevent the complications of this condition. |
| Databáze: | OpenAIRE |
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