Chronic Exposure to Bisphenol A can Accelerate Atherosclerosis in High-Fat-Fed Apolipoprotein E Knockout Mice
| Autor: | Geun Hyung Kang, Min Joo Kim, Do Joon Park, Sung Hee Choi, Soo Lim, Hak Chul Jang, Kwan Jae Lee, Min Kyong Moon, Kyong Soo Park, Young Joo Park, Byung-Chul Oh |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Apolipoprotein E endocrine system medicine.medical_specialty Time Factors Aortic Diseases Diet High-Fat Toxicology Umbilical vein Apolipoproteins E Cholesterol Dietary chemistry.chemical_compound Phenols Risk Factors Internal medicine medicine.artery Human Umbilical Vein Endothelial Cells medicine Animals Humans Oil Red O Benzhydryl Compounds Molecular Biology Aorta Cells Cultured Mice Knockout urogenital system Cholesterol business.industry Atherosclerosis Up-Regulation Disease Models Animal Endocrinology chemistry Knockout mouse Environmental Pollutants lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Biomarkers hormones hormone substitutes and hormone antagonists Lipoprotein |
| Zdroj: | Cardiovascular Toxicology. 14:120-128 |
| ISSN: | 1559-0259 1530-7905 |
| Popis: | In epidemiological studies, there is growing concern regarding the association between human exposure to bisphenol A (BPA) and an increased risk for cardiovascular disease. Therefore, we investigated whether BPA accelerates atherosclerosis in mouse model. Apolipoprotein E knockout (ApoE(-/-)) mice were fed a high-fat and high-cholesterol diet with or without 50 μg/kg body weight/day BPA for 12 weeks. Atherosclerotic lesions of the aorta and aortic sinus were evaluated by Oil red O staining. After the 12-week BPA treatment, BPA significantly increased atherosclerotic lesions in the aortas of ApoE(-/-) mice by 1.7-fold (p = 0.03). Non-high-density lipoprotein (HDL) cholesterol levels in the BPA group were significantly higher compared to those in the control group (1,035 ± 70 vs. 484 ± 48 mg/dL, p = 0.02) although body weight and blood glucose levels were not different between groups. Human umbilical vein endothelial cells (HUVECs) were treated with 0.1-10 nM BPA but BPA did not affect HUVEC proliferation or migration. BPA could accelerate atherosclerosis in ApoE(-/-) mice, which may have resulted from an increase in non-HDL cholesterol levels. |
| Databáze: | OpenAIRE |
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