Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort
| Autor: | Janie Corley, S. Muñoz Maniega, M. del C. Valdés Hernández, Joanna M. Wardlaw, Lucia Ballerini, Mark E. Bastin, Paul Redmond, Simon R. Cox, Ian J. Deary, Alan J. Gow, Olivia K.L. Hamilton |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Aging medicine.medical_specialty Cerebral small vessel disease Disease Audiology Article Cohort Studies 03 medical and health sciences Cognitive aging 0302 clinical medicine Cognition medicine White matter hyperintensities Humans Cognitive Dysfunction Association (psychology) Cerebrovascular disease Disease burden Aged business.industry General Neuroscience Brain Acc/In press Visuospatial ability Magnetic Resonance Imaging Hyperintensity 030104 developmental biology Cerebral Small Vessel Diseases Cohort Vascular cognitive impairment Female Neurology (clinical) Small vessel Independent Living Geriatrics and Gerontology Verbal memory business LBC1936 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Neurobiology of Aging Hamilton, OKL, Cox, SR, Ballerini, L, Bastin, ME, Corley, J, Gow, AJ, Muñoz Maniega, S, Redmond, P, M del C, V-H, Wardlaw, JM & Deary, IJ 2021, ' Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort ', Neurobiology of Aging, vol. 105, pp. 2021.02.02.21250986 . https://doi.org/10.1016/j.neurobiolaging.2021.04.007 Neurobiol Aging |
| ISSN: | 1558-1497 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2021.04.007 |
| Popis: | Highlights • Greater SVD burden associates with poorer abilities in all major cognitive domains. • SVD associates with memory and visuospatial due to covariance with general ability. • However, SVD’s association with processing speed is independent of general ability. • Continuous radiological variables improve fidelity of SVD burden quantification. • All major cognitive domains should be tested in SVD research and clinical settings. Cerebral small vessel disease (SVD) is a leading cause of vascular cognitive impairment, however the precise nature of SVD-related cognitive deficits, and their associations with structural brain changes, remain unclear. We combined computational volumes and visually-rated MRI markers of SVD to quantify total SVD burden, using data from the Lothian Birth Cohort 1936 (n = 540; age: 72.6 ± 0.7 years). We found negative associations between total SVD burden and general cognitive ability (standardized β: -0.363; 95%CI: [-0.49, -0.23]; p(FDR) < 0.001), processing speed (-0.371 [-0.50, -0.24]; p(FDR) < 0.001), verbal memory (-0.265; [-0.42, -0.11]; p(FDR) = 0.002), and visuospatial ability (-0.170; [-0.32, -0.02]; p(FDR) = 0.029). Only the association between SVD burden and processing speed remained after accounting for covariance with general cognitive ability (-0.325; [-0.61, -0.04]; p(FDR) = 0.029). This suggests that SVD's association with poorer processing speed is not driven by, but is independent of its association with poorer general cognitive ability. Tests of processing speed may be particularly sensitive to the cognitive impact of SVD, but all major cognitive domains should be tested to determine the full range of SVD-related cognitive characteristics. |
| Databáze: | OpenAIRE |
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