Test procedures for obtaining representative extracts suitable for reliable in vitro toxicity assessment of paper and board intended for food contact
| Autor: | E.L. Bradley, A. Stammati, M. Salkinoja-Salonen, M. Andersson, F. Bertaud, D. Hoornstra, F. Zucco, A. Weber, L. Turco, H. Traussnig, P. Hakulinen, D.R. Speck, A.J. Von Wright, U. Honkalampi-Hämäläinen, J. Mäki-Paakkanen, I. Severin, J.-C. Lhuguenot, O. Dahlman |
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| Přispěvatelé: | The Food and Environment Research Agency, Ajouter cet établissement, Istituto Superiore di Sanità, Department of Environmental and Primary Prevention, University of Helsinki, Department of Applied Chemistry and Microbiology, Kungliga, Tekniska Hogskolan, Kungliga Tekniska Hogskolan, Centre Technique du Papier Hoornstra, Douwe, Istituto di Neurobiologia e Medicina Molecolare, KCL Science and Consulting, Ajo, Mayr-Melnhof Karton Gesellschaft m.b.H, National Public Health Institute, Department of Environmental Health, University of Kuopio, Institute of Applied Biotechnology, Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), STFI-Packforsk AB, Department of Environmental and Primary Prevention, Istituto Superiore di Sanita [Rome], Department of Applied Chemistry and Microbiology, Centre Technique du Papier (CTP), Department of Environmental Health, National Public Health Institute, Institute of Applied Biotechnology, University of Kuopio, Department of Biosciences, Laboratoire Toxicologie Alimentaire, Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Paper
Food contact materials Health Toxicology and Mutagenesis Sample (material) [ SDV.TOX ] Life Sciences [q-bio]/Toxicology Tenax [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain In Vitro Techniques Toxicology Paper and board MESH : Gas Chromatography-Mass Spectrometry 01 natural sciences MESH : Food Packaging Gas Chromatography-Mass Spectrometry MESH : Toxicity Tests 0404 agricultural biotechnology Toxicity Tests Bioassay Paperboard MESH : Wood Food contact business.industry Test procedures 010401 analytical chemistry Extraction (chemistry) Food Packaging Public Health Environmental and Occupational Health Life Sciences 04 agricultural and veterinary sciences General Chemistry General Medicine Pulp and paper industry Toxicity assessment Wood 040401 food science 0104 chemical sciences Biotechnology MESH : Paper In vitro testing Extraction procedures visual_art visual_art.visual_art_medium Environmental science business Food Science |
| Zdroj: | Food Addit Contam Part A Chem Anal Control Expo Risk Assess Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2010, 27 (2), pp.262-71. 〈10.1080/02652030903232746〉 Food Additives and Contaminants Food Additives and Contaminants, 2009, 27 (02), pp.262-271. ⟨10.1080/02652030903232746⟩ |
| DOI: | 10.1080/02652030903232746〉 |
| Popis: | International audience; This paper describes the use of a suite of extraction procedures applicable to the assessment of the in vitro toxicity of paper/board samples intended for food-contact applications. The sample is extracted with ethanol, water, or exposed to modified polyphenylene oxide (Tenax) for fatty, non-fatty and dry food applications, respectively. The water extracts are directly suitable for safety assessment using in vitro bioassays. The ethanol extracts of the paper/board and of the exposed Tenax require pre-concentration to give acceptable sensitivity. This is because the in vitro bioassays can tolerate only a small percentage of added organic solvent before the solvent itself inhibits. The extraction procedures have been selected such that they mimic the foreseeable conditions of use with foods and that they are also fully compatible with the battery of in vitro biological assays for the safety assessment of the total migrate. The application of the extraction protocols is illustrated by the results for one of the many paper/board samples provided by the BIOSAFEPAPER project industrial platform members. The assessment indicated that this sample should not be considered as suitable for use with fatty foodstuffs but was suitable for dry and non-fatty foods. Information subsequently received from the manufacturer revealed that this was a non-food-grade product included in the project to test the capabilities of the bioassay procedures. The selection criteria for the test conditions and the suite of methods developed have been prepared in Comité Européen de Normalisation (CEN) format and is currently being progressed by CEN/TC172 as a European Standard. |
| Databáze: | OpenAIRE |
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