Antioxidant and Antiamnestic Effects of Potassium Comenate and Comenic Acid under Conditions of Normobaric Hypoxia with Hypercapnia
| Autor: | A. A. Kravtsov, L. V. Shurygina, A. N. Kravtsova, E. I. Zlishcheva |
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| Rok vydání: | 2017 |
| Předmět: |
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medicine.medical_specialty Antioxidant medicine.medical_treatment Carboxylic Acids 030226 pharmacology & pharmacy Antioxidants General Biochemistry Genetics and Molecular Biology Comenic acid Hypercapnia 03 medical and health sciences 0302 clinical medicine Memory Malondialdehyde Internal medicine Conditioning Psychological medicine Animals Rats Wistar Hypoxia Maze Learning Nootropic Agents Normobaric hypoxia Chemistry Conditioned reflex Brain General Medicine Hypoxia (medical) Rats Endocrinology Pyrones Potassium comenate medicine.symptom Reactive Oxygen Species 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 163:344-348 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-017-3800-4 |
| Popis: | Potassium comenate and comenic acid exhibit manifest and virtually identical antioxidant activity under conditions of hypoxia with hypercapnia. The effects of these drugs on conditioned reflex training with positive reinforcement differ significantly. Potassium comenate promotes retention of the learning capacity and memory in hypoxic rats at the level of intact control, that is, exhibits a pronounced protective antiamnestic effect, while comenic acid only facilitates training of the conditioned reflex with positive reinforcement. |
| Databáze: | OpenAIRE |
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