Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from dioncophyllaceae and ancistrocladaceae species
| Autor: | Gerhard Bringmann, Georges Timperman, C. Zhao, S. A. Robertson, R. D. Haller, Sabine Bär, N.J. De Souza, Jörg Holenz, Guido François, Tania Steenackers, M. A. Isahakia, L. Ake Assi |
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| Rok vydání: | 1997 |
| Předmět: |
Carcinoma
Hepatocellular Plasmodium berghei Rodentia Pharmacognosy Plant Roots Cell Line Antimalarials chemistry.chemical_compound parasitic diseases Botany Tumor Cells Cultured Animals Humans Parasite hosting Plants Medicinal Plant Stems Traditional medicine biology Plant Extracts Liver Neoplasms biology.organism_classification Malaria Dioncophyllaceae Hep G2 Infectious Diseases chemistry Triphyophyllum Parasitology Medicine Traditional Ancistrocladaceae Growth inhibition |
| Zdroj: | International Journal for Parasitology. 27:29-32 |
| ISSN: | 0020-7519 |
| DOI: | 10.1016/s0020-7519(96)00171-3 |
| Popis: | Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceae and Ancistrocladaceae species. International Journal for Parasitology 27: 29–32. Naphthylisoquinoline alkaloid-containing extracts (10 μg ml−1) of species belonging to the Dioncophyllaceae and the Ancistrocladaceae, 2 small tropical plant families, display pronounced in vitro activities against exoerythrocytic stages of Plasmodium berghei (Anka), developing in human hepatoma cells (Hep G2). The highest activities were obtained with CH2Cl2 root and bark extracts, and a CH 2 Cl 2 NH 3 leaf extract from Triphyophyllum peltatum, a CH 2 Cl 2 NH 3 root extract from Ancistrocladus abbreviatus, and a CH2Cl2 leaf extract from A. tectorius. The degrees of growth inhibition ranged within 27.7–70.0%. The commercially available drug primaquine diphosphate (25 μg ml−1) caused a comparable effect (62.1%) in the same test system. |
| Databáze: | OpenAIRE |
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