Plasma 25-hydroxyvitamin D concentration and risk of type 2 diabetes and pre-diabetes: 12-year cohort study

Autor: Cedric F. Garland, Edward D. Gorham, Luke BuDoff, Sue K. Park, Elizabeth Barrett-Connor
Rok vydání: 2018
Předmět:
Male
Physiology
Organic chemistry
lcsh:Medicine
Type 2 diabetes
Body Mass Index
Cohort Studies
Endocrinology
0302 clinical medicine
Risk Factors
Blood plasma
Medicine and Health Sciences
030212 general & internal medicine
Prediabetes
Vitamin D
lcsh:Science
Aged
80 and over
Glucose tolerance test
Multidisciplinary
medicine.diagnostic_test
Vitamins
Middle Aged
Body Fluids
Type 2 Diabetes
3. Good health
Physical sciences
Chemistry
Blood
Nutritional deficiencies
Physiological Parameters
Research Design
Female
Anatomy
Research Article
Adult
medicine.medical_specialty
Endocrine Disorders
030209 endocrinology & metabolism
Research and Analysis Methods
Lower risk
Blood Plasma
vitamin D deficiency
Prediabetic State
Chemical compounds
03 medical and health sciences
Internal medicine
Diabetes mellitus
Organic compounds
Diabetes Mellitus
medicine
Vitamin D and neurology
Humans
Aged
Nutrition
Vitamin D deficiency
business.industry
Body Weight
lcsh:R
Biology and Life Sciences
Glucose Tolerance Test
medicine.disease
Diabetes Mellitus
Type 2
Metabolic Disorders
Dietary Supplements
Calcium
lcsh:Q
business
Zdroj: PLoS ONE, Vol 13, Iss 4, p e0193070 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: Background It has been reported that higher plasma 25-hydroxyvitamin D is associated with lower risk of type 2 diabetes. However the results to date have been mixed and no adequate data based on a cohort are available for the high end of the normal range, above approximately 32 ng/ml or 80 nmol/L. Methods We performed a cohort study of 903 adults who were known to be free of diabetes or pre-diabetes during a 1997–1999 visit to a NIH Lipid Research Centers clinic. Plasma 25(OH)D was measured at Visit 8 in 1977–1979. The mean age was 74 years. The visit also included fasting plasma glucose and oral glucose tolerance testing. Follow-up continued through 2009. Results There were 47 cases of diabetes and 337 cases of pre-diabetes. Higher 25(OH)D concentrations (> 30 ng/ml) were associated with lower hazard ratios (HR) for diabetes: 30–39 ng/ml or 75–98 nmol/L: HR = 0.31, 95% CI = 0.14–0.70; for 40–49 ng/ml or 100–122 nmol/L: HR = 0.29, CI = 0.12–0.68; for > 50 ng/ml or 125 nmol/L: HR = 0.19, CI = 0.06–0.56. All HRs are compared to < 30 ng/ml or 75 nmol/L. There was an inverse dose-response gradient between 25(OH)D concentration and risk of diabetes with a p for trend of 0.005. Each 10 ng/mL or 25 nmol/L higher 25(OH)D concentration was associated with a HR of 0.64, CI = 0.48–0.86. 25(OH)D concentrations were more weakly inversely associated with pre-diabetes risk, and the trend was not significant. Conclusion Further research is needed on whether high 25(OH)D might prevent type 2 diabetes or transition of prediabetes to diabetes.
Databáze: OpenAIRE
Externí odkaz: