Nimotuzumab for Patients With Inoperable Cancer of the Head and Neck
| Autor: | Braulio Mestre Fernández, Zaima Mazorra Herrera, Normando E Iznaga Escobar, Tania Crombet Ramos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research EGFR medicine.medical_treatment Review lcsh:RC254-282 Metastasis head and neck 03 medical and health sciences 0302 clinical medicine medicine Nimotuzumab Progression-free survival radiotherapy Cisplatin Chemotherapy nimotuzumab business.industry Cancer lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Radiation therapy 030104 developmental biology Oncology monoclonal antibody 030220 oncology & carcinogenesis Cancer cell Cancer research business medicine.drug |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 10 (2020) |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2020.00817 |
| Popis: | EGFR activation induces cell proliferation, neoformation of blood vessels, survival, and metastasis of the cancer cells. Nimotuzumab is an engineered, intermediate affinity anti-EGFR antibody, that apart from other drugs in its class, is very safe and does not cause hypomagnesemia or grade 3–4 cutaneous rash. The antibody inhibits cell proliferation and angiogenesis, activates natural killer cells, stimulates dendritic cell maturation, and induces cytotoxic T cells. Nimotuzumab restores MHC-I expression on tumor cells, hindering one of the EGFR immune-escape ways. The antibody has been extensively studied in 7 clinical trials, concurrently with irradiation or irradiation plus chemotherapy in subjects with inoperable head and neck tumors. Nimotuzumab was safe and efficacious in unfit patients receiving irradiation alone and in subjects treated with cisplatin and radiotherapy. In patients with locally advanced squamous cell carcinomas of the head and neck, nimotuzumab in combination with low dose cisplatin and radiotherapy was superior to cisplatin and radiotherapy in progression free survival, disease free survival, and locoregional tumor control. |
| Databáze: | OpenAIRE |
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