Gut-derived acetate promotes B10 cells with antiinflammatory effects
Autor: | Duan Ni, Alexandra Sophie Angelatos, Charles R. Mackay, M.C.B. Amian, Claire Daien, Stephen J. Simpson, Remy Robert, M. Duraes, Jian Tan, S. Hoque, Alison K. Gosby, Rosilene V Ribeiro, Lake-Ee Quek, R. Audo, J. Mielle, Gabriela Pinget, A. Parmar, M.J. Alam, Laurence Macia, Frederic Sierro, James R. Krycer, G. Perkins |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Dietary Fiber Male Neutrophils Regulatory B cells Cellular differentiation Immunology chemical and pharmacologic phenomena Acetates Immune tolerance Receptors G-Protein-Coupled 03 medical and health sciences 0302 clinical medicine Immune system In vivo Acetyl Coenzyme A Animals Humans 2. Zero hunger B-Lymphocytes Regulatory Chemistry Beta cells Acetylation Cell Differentiation General Medicine Metabolism Fatty Acids Volatile Arthritis Experimental In vitro Mice Mutant Strains 3. Good health Cell biology Interleukin-10 Mice Inbred C57BL 030104 developmental biology 030220 oncology & carcinogenesis Medicine Female Research Article |
Zdroj: | JCI Insight JCI Insight, Vol 6, Iss 7 (2021) |
ISSN: | 2379-3708 |
Popis: | Autoimmune diseases are characterized by a breakdown of immune tolerance partly due to environmental factors. The short-chain fatty acid acetate, derived mostly from gut microbial fermentation of dietary fiber, promotes antiinflammatory Tregs and protects mice from type 1 diabetes, colitis, and allergies. Here, we show that the effects of acetate extend to another important immune subset involved in tolerance, the IL-10–producing regulatory B cells (B10 cells). Acetate directly promoted B10 cell differentiation from mouse B1a cells both in vivo and in vitro. These effects were linked to metabolic changes through the increased production of acetyl-coenzyme A, which fueled the TCA cycle and promoted posttranslational lysine acetylation. Acetate also promoted B10 cells from human blood cells through similar mechanisms. Finally, we identified that dietary fiber supplementation in healthy individuals was associated with increased blood-derived B10 cells. Direct delivery of acetate or indirect delivery via diets or bacteria that produce acetate might be a promising approach to restore B10 cells in noncommunicable diseases. |
Databáze: | OpenAIRE |
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