Amyloid‐β associated cortical thinning in clinically normal elderly
| Autor: | Donald Marks, Randy L. Buckner, Gad A. Marshall, Deepti Putcha, Jacqueline E. Maye, Jeremy Carmasin, Keith A. Johnson, Bruce Fischl, Douglas N. Greve, J. Alex Becker, Stephen Salloway, Reisa A. Sperling, Trey Hedden, Dorene M. Rentz |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Aging Pathology medicine.medical_specialty Statistics as Topic Precuneus Hippocampus Brain mapping 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Atrophy Alzheimer Disease medicine Humans Aged 030304 developmental biology Aged 80 and over Cerebral Cortex Analysis of Variance Brain Mapping 0303 health sciences Amyloid beta-Peptides Aniline Compounds medicine.diagnostic_test Age Factors Magnetic resonance imaging Original Articles Middle Aged medicine.disease Magnetic Resonance Imaging Thiazoles medicine.anatomical_structure Neurology chemistry Cerebral cortex Positron-Emission Tomography Posterior cingulate Female Neurology (clinical) Alzheimer's disease Pittsburgh compound B Psychology 030217 neurology & neurosurgery |
| Zdroj: | Annals of Neurology |
| ISSN: | 1531-8249 0364-5134 |
| Popis: | Objective: Both amyloid-b (Ab) deposition and brain atrophy are associated with Alzheimer’s disease (AD) and the disease process likely begins many years before symptoms appear. We sought to determine whether clinically normal (CN) older individuals with Ab deposition revealed by positron emission tomography (PET) imaging using Pittsburgh Compound B (PiB) also have evidence of both cortical thickness and hippocampal volume reductions in a pattern similar to that seen in AD. Methods: A total of 119 older individuals (87 CN subjects and 32 patients with mild AD) underwent PiB PET and high-resolution structural magnetic resonance imaging (MRI). Regression models were used to relate PiB retention to cortical thickness and hippocampal volume. Results: We found that PiB retention in CN subjects was (1) age-related and (2) associated with cortical thickness reductions, particularly in parietal and posterior cingulate regions extending into the precuneus, in a pattern similar to that observed in mild AD. Hippocampal volume reduction was variably related to Ab deposition. Interpretation: We conclude that Ab deposition is associated with a pattern of cortical thickness reduction consistent with AD prior to the development of cognitive impairment. ANN NEUROL 2010;000:000–000 |
| Databáze: | OpenAIRE |
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