Urodynamic measurements reflect physiological bladder function in rats
| Autor: | Andrea M. Sartori, Juliane Tampé, Benjamin V. Ineichen, Martin E. Schwab, Selina Moors, Marc P. Schneider, Anne K. Engmann, Anna-Sophie Hofer, Thomas M. Kessler |
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| Přispěvatelé: | University of Zurich, Kessler, Thomas M |
| Rok vydání: | 2017 |
| Předmět: |
2748 Urology
medicine.medical_specialty Urology Urinary Bladder 030232 urology & nephrology Clinical Neurology Urination 610 Medicine & health Electromyography 03 medical and health sciences 0302 clinical medicine Urethra Active phase Lewis rats Medicine Animals Circadian rhythm medicine.diagnostic_test 10242 Brain Research Institute business.industry Urethral sphincter Rats Catheter Urodynamics 2728 Neurology (clinical) Rats Inbred Lew Models Animal 10046 Balgrist University Hospital Swiss Spinal Cord Injury Center Female Neurology (clinical) business Bladder function Cage 030217 neurology & neurosurgery |
| Zdroj: | Neurourology and urodynamics. 37(4) |
| ISSN: | 1520-6777 |
| Popis: | Aims Our objective was to investigate and compare bladder function in rats assessed by metabolic cage and by urodynamic measurements in fully awake animals. Methods Bladder function of female Lewis rats was investigated in naive animals by metabolic cage at baseline, 14-16 days after bladder catheter and external urethral sphincter electromyography electrode implantation in fully awake animals by urodynamics, and again by metabolic cage. Results Investigating the same animals (n = 8), voided volume, average flow, and duration of voiding were similar (P > 0.05) in naive animals measured by metabolic cage and after catheter implantation by urodynamic measurements and by metabolic cage. In naive animals measured by metabolic cage, voided volumes were significantly different in the light (resting phase) versus the dark (active phase) part of the 24 h cycle (mean difference 0.14 mL, 21%, P = 0.004, n = 27). Conclusions Lower urinary tract function assessed by metabolic cage or by urodynamic meaurements in fully awake rats was indistinguishable. Thus, catheter implantation did not significantly change physiological bladder function. This shows that urodynamic measurements in awake animals are an appropriate approach to study lower urinary tract function in health and disease in animal models, directly paralleling the human diagnostic procedures. |
| Databáze: | OpenAIRE |
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