Synthesis of phosphaisocoumarin amidates via DIBAL-H-mediated selective amidation of phosphaisocoumarin esters

Autor:	Bo Wang, Pei-Jiang Chen, Ai-Yun Peng, Yu-Juan Guo
Rok vydání:	2014
Předmět:	Magnetic Resonance Spectroscopy Chemistry Stereochemistry Organic Chemistry High selectivity Organophosphonates Esters Ring (chemistry) Biochemistry Combinatorial chemistry Amides Isocoumarins Alkoxy group Organometallic Compounds Physical and Theoretical Chemistry Amines
Zdroj:	Organicbiomolecular chemistry. 12(29)
ISSN:	1477-0539
Popis:	A series of phosphaisocoumarin amidates were synthesized for the first time via DIBAL-H-mediated direct amidation of phosphaisocoumarin esters under mild conditions in good to excellent yields. The present reaction showed high selectivity. In each case, the phostone ring was intact and only the exocyclic ethoxy group was amidated. A plausible mechanism of the reaction was provided.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3e050599aa1e7c16737551fb744059 https://pubmed.ncbi.nlm.nih.gov/24942670 Zobrazit plný text záznamu