Control of multiple arthropod vector infestations with subolesin/akirin vaccines
| Autor: | José De la Fuente, Atilio José Mangold, Ard Nijhof, Sarah Angele Delacour Estrella, Carlos Prudencio, José Manuel Pérez de la Lastra, Maribel Jiménez, Ricardo Molina, Christian Gortazar, Margarita M. Villar-Rayo, Agustín Estrada Peña, Ignacio Ruiz Arrondo |
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| Přispěvatelé: | Consejo Superior de Investigaciones Científicas (España) |
| Rok vydání: | 2013 |
| Předmět: |
Male
Oviposition Recombinant Fusion Proteins Arthropod Molecular Sequence Data Immunology Tick Arthropod Proteins Mice Ticks Mosquito parasitic diseases Animals Humans Subolesin Mice Inbred BALB C Vaccines Synthetic General Veterinary General Immunology and Microbiology Animal health biology Vaccination fungi Public Health Environmental and Occupational Health Arthropod Vectors Sequence Analysis DNA biology.organism_classification Virology Survival Analysis Tick Infestations Infectious Diseases Culicidae Fertility Vector (epidemiology) Sand fly Akirin Molecular Medicine Female Psychodidae Vaccine Arthropod Vector |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Diseases transmitted by arthropod vectors such as mosquitoes, ticks and sand flies greatly impact human and animal health and thus their control is important for the eradication of vector-borne diseases (VBD). Vaccination is an environmentally friendly alternative for vector control that allows control of several VBD by targeting their common vector. Recent results have suggested that subolesin/akirin (SUB/AKR) is good candidate antigens for the control of arthropod vector infestations. Here we describe the comparative effect of vaccination with SUB, AKR and Q38 and Q41 chimeras containing SUB/AKR conserved protective epitopes on tick, mosquitoes and sand flies vector mortality, molting, oviposition and/or fertility. We demonstrated that SUB vaccination had the highest efficacy (E) across all vector species (54-92%), Q41 vaccination had the highest vaccine E in mosquitoes (99%) by reducing female survival and fertility, and Q38 vaccination had the highest effect on reducing mosquito (28%) and sand fly (26%) oviposition. The effect of vaccination on different developmental processes in several important arthropod vectors encourages the development of SUB/AKR universal vaccines for the control of multiple vector infestations and reduction of VBD. This research was supported by grants FAU2008-00014-00-00 and PEII09-0118-8907 to JF. M. Villar was funded by the JAE-DOC program (CSIC-FSE), Spain. |
| Databáze: | OpenAIRE |
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