Dermatitis herpetiformis: A review of fifty-four patients
| Autor: | S. O’Loughlin, Frank C. Powell, S. Gormally, C. A. Egan |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Biopsy Dermatitis Herpetiformis Dapsone Coeliac disease Risk Factors Dermatitis herpetiformis Humans Medicine Intestinal Mucosa Family history Adverse effect Aged Skin Dermoepidermal junction business.industry General Medicine Middle Aged medicine.disease Dermatology Immunoglobulin A Surgery Celiac Disease Fluorescent Antibody Technique Direct Female Gluten free Age of onset business medicine.drug |
| Zdroj: | Irish Journal of Medical Science. 166:241-244 |
| ISSN: | 1863-4362 0021-1265 |
| DOI: | 10.1007/bf02944243 |
| Popis: | A review of 54 patients with dermatitis herpetiformis presenting between 1984-1993 to The Regional Centre of Dermatology, Mater Misericordiae Hospital was undertaken. All patients had skin lesions clinically and histologically typical of dermatitis herpetiformis. Deposition of granular IgA at the dermoepidermal junction on direct immunofluorescence was present in each case. The average age of onset was 41.8 yr, patients having symptoms for an average of 1.6 yr before diagnosis. Six patients had a prior history of coeliac disease. Two patients had a family history of dermatitis herpetiformis, a father and son who were both propositi in this study. Small bowel biopsy was performed on 35 patients, 71.4 per cent of them showing evidence of villous atrophy. All patients were controlled on a gluten free diet or by dapsone or a combination of these. None of the patients experienced serious adverse effects of therapy, nor did any develop lymphoma of the small bowel with a mean follow up period of 4.2 yr (range 1-10 yr). |
| Databáze: | OpenAIRE |
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