Myoblast Stored Myosin Heavy Chain Transcripts are Precursors to the Myotube Polysomal Myosin Heavy Chain mRNAs*
| Autor: | Eric J. Siegel, Thomas Doetschman, Haviv P. Dym, Stuart M. Heywood |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Cancer Research
Messenger RNA Transcription Genetic Muscles Period (gene) Embryogenesis Cell Differentiation chemical and pharmacologic phenomena Embryo Chick Embryo Cell Biology Myosins Biology Major histocompatibility complex Molecular biology Cell culture Myosin biology.protein Animals Myocyte RNA Messenger Protein Precursors Molecular Biology Developmental Biology |
| Zdroj: | Differentiation. 16:149-162 |
| ISSN: | 0301-4681 |
| DOI: | 10.1111/j.1432-0436.1980.tb01071.x |
| Popis: | Radioactively labeled myosin heavy chain messenger ribonucleic acid (MHC mRNA) synthesized during the pre-fusion stage of chick embryo breast muscle cell culture is transferred from messenger ribonucleic acid proteins (mRNPs) to the polysomal MHC mRNA during the period of rapid increase in the rate of MHC synthesis (mid-to late-fusion). This transfer constitutes a major contribution to the rate of incorporation of 3H-labeled transcripts into polysomal MHC mRNA at this time. As the increase in the rate of MHC synthesis levels off (late-to post-fusion) the contribution to the rate of incorporation of 3H-labeled transcripts into polysomal MHC mRNA from newly synthesized transcripts increases until it becomes predominant. In vivo, the level of MHC mRNP increases during early stages of embryonic development and then decreases when MHC synthesis and the level of polysomal MHC mRNA has been shown to increase. |
| Databáze: | OpenAIRE |
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