Low-dose combination of alendronate and atorvastatin reduces ligature-induced alveolar bone loss in rats
| Autor: | N. M. N. Alencar, Paula Goes, Vilma Lima, Norma Maria Barros Benevides, Ronaldo A. Ribeiro, Luana Maria Castelo Melo Silva, Iracema Matos Melo |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Anabolism Leukocytosis Neutrophils Injections Subcutaneous medicine.medical_treatment Atorvastatin Acid Phosphatase Alveolar Bone Loss Gingiva Root Resorption Monocytes Transaminase Internal medicine Leukocytes medicine Animals Infusions Parenteral Pyrroles Aspartate Aminotransferases Rats Wistar Saline Dental alveolus Peroxidase Dental Cementum Alendronate Bone Density Conservation Agents Tartrate-Resistant Acid Phosphatase Chemistry Body Weight Alanine Transaminase Alkaline Phosphatase Neutrophilia Resorption Surgery Isoenzymes Endocrinology Heptanoic Acids Periodontics Alkaline phosphatase Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.symptom Leukocyte Disorders medicine.drug |
| Zdroj: | Journal of Periodontal Research. 49:45-54 |
| ISSN: | 0022-3484 |
| DOI: | 10.1111/jre.12077 |
| Popis: | Background and Objective Atorvastatin (ATV) has bone anabolic properties, and alendronate (ALD) is an important antiresorptive drug. This study aimed to evaluate the effects of the combination of ALD and ATV on ligature-induced alveolar bone loss in rats. Material and Methods Periodontitis was induced by ligature in 78 Wistar rats. Groups of six rats prophylactically received 0.9% saline (SAL), ALD (0.01 or 0.25 mg/kg subcutaneously) or ATV (0.3 or 27 mg/kg by gavage). Then, groups of six rats received the combination of ALD+ATV (0.25 mg/kg + 27 mg/kg, 0.01 mg/kg + 0.3 mg/kg, 0.25 mg/kg + 0.3 mg/kg or 0.01 mg/kg + 27 mg/kg) prophylactically. An extra group of six rats received therapeutic SAL or a lower-dose combination of ALD+ATV (0.01 mg/kg + 0.3 mg/kg, respectively) therapeutically. Three extra groups of six rats each received SAL or a lower-dose combination of ALD+ATV (0.01 mg/kg + 0.3 mg/kg, respectively) prophylactically or therapeutically for histometric and immunohistochemical analyses. The rats were killed on day 11 after ligature placement, and the maxillae were removed and processed for macroscopic, histomorphometric and TRAP immunohistochemical analyses. Gingival samples were collected to evaluate myeloperoxidase (MPO) activity. Blood samples were collected to measure serum bone-specific alkaline phosphatase (BALP) and transaminase levels and for hematological studies. Rats were weighed daily. Results All combined therapies prevented alveolar bone loss when compared with SAL or low doses of monotherapy (ALD or ATV) (p |
| Databáze: | OpenAIRE |
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