Foveal structure and visual function in nanophthalmos and posterior microphthalmos
| Autor: | Paul J. Foster, Tim Treis, Mariya Moosajee, Peng T. Khaw, Louisa Wickham, Catherine A Egan, Dilani Siriwardena, Andrew R. Webster, Adnan Tufail, Carlos Pavesio, Abdulrahman Alsaedi, Michel Michaelides, Philipp L. Müller |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Fovea Centralis medicine.medical_specialty Refractive error Visual acuity genetic structures Visual Acuity 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Optical coherence tomography Foveal Ophthalmology medicine Humans Microphthalmos Outer nuclear layer Retrospective Studies Retina medicine.diagnostic_test business.industry Retinal Refractive Errors medicine.disease eye diseases Sensory Systems Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure chemistry Case-Control Studies 030221 ophthalmology & optometry sense organs medicine.symptom business Choroidal Effusions Tomography Optical Coherence |
| Zdroj: | British Journal of Ophthalmology. :bjophthalmol-2020 |
| ISSN: | 1468-2079 0007-1161 |
| Popis: | Background/aimsThe reason for visual impairment in patients with nanophthalmos and posterior microphthalmos is not completely understood. Therefore, this study aims to investigate foveal structure, and the impact of demographic, clinical and imaging parameters on best-corrected visual acuity (BCVA) in these conditions.MethodsSixty-two eyes of 33 patients with nanophthalmos (n=40) or posterior microphthalmos (n=22), and 114 eyes of healthy controls with high-resolution retinal imaging including spectral-domain or swept-source optical coherence tomography images were included in this cross-sectional case–control study. Foveal retinal layer thickness was determined by two independent readers. A mixed-effect model was used to perform structure–function correlations and predict the BCVA based on subject-specific variables.ResultsMost patients (28/33) had altered foveal structure associated with loss of foveal avascular zone and impaired BCVA. However, widening of outer nuclear layer, lengthening of photoreceptor outer segments, normal distribution of macular pigment and presence of Henle fibres were consistently found. Apart from the presence of choroidal effusion, which had significant impact on BCVA, the features age, refractive error, axial length and retinal layer thickness at the foveal centre explained 61.7% of the variability of BCVA.ConclusionThis study demonstrates that choroidal effusion, age, refractive error, axial length and retinal layer thickness are responsible for the majority of interindividual variability of BCVA as well as the morphological foveal heterogeneity in patients with nanophthalmos or posterior microphthalmos. This might give further insights into the physiology of foveal development and the process of emmetropisation, and support clinicians in the assessment of these disease entities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|