Antimicrobial Activities of Some Pyrazoline and Hydrazone Derivatives
| Autor: | Suna Sibel Gürpinar, Begüm Evranos Aksöz, Müjde Eryilmaz |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Antifungal antimicrobial activity synthesis Traditional medicine Chemistry medicine.drug_class Antibiotics lcsh:RS1-441 Pharmaceutical Science Hydrazone Pyrazoline Antimicrobial hydrazone derivatives lcsh:Pharmacy and materia medica Human health Minimum inhibitory concentration chemistry.chemical_compound Derivative (finance) medicine Molecular Medicine Original Article pyrazoline derivatives |
| Zdroj: | Turkish Journal of Pharmaceutical Sciences, Vol 17, Iss 5, Pp 500-505 (2020) Turk J Pharm Sci |
| ISSN: | 2148-6247 1304-530X |
| DOI: | 10.4274/tjps.galenos.2019.42650 |
| Popis: | Objectives Resistance to antibiotics is recognized as one of the biggest threats to human health worldwide. Frequent and unnecessary use of antibiotics has caused infectious agents to adapt to antibiotics and thus drugs have become less effective. The resistance to many antibiotics necessitates the discovery of new antibiotics. In this study, two new and 23 previously reported 2-pyrazoline derivatives and one hydrazone derivative were evaluated for their in vitro antibacterial and antifungal activities. Materials and methods For the determination of the minimum inhibitory concentration (MIC) values of compounds, microbroth dilution was used. Results The antimicrobial activities of the compounds were found in a wide range with MIC values of 32-512 μg/mL. Conclusion The synthesized compounds showed moderate antimicrobial activity compared with the standards. They can be used as lead molecules for the synthesis of more effective compounds. |
| Databáze: | OpenAIRE |
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