Estrogenic inhibition of testicular growth by R2858 in preweanling rats
| Autor: | M. T. Tseng, J. P. Friend |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Pharmacology
Male endocrine system medicine.medical_specialty Dose-Response Relationship Drug Leydig Cells Cell Biology Testicular growth Biology Animal Population Groups Animals Suckling Rats Cellular and Molecular Neuroscience Endocrinology Estradiol Congeners Internal medicine Depression Chemical Testis medicine Ultrastructure Molecular Medicine Animals alpha-Fetoproteins Molecular Biology |
| Zdroj: | Experientia. 36(12) |
| ISSN: | 0014-4754 |
| Popis: | Daily injections of physiologic doses of R2858 into preweanling rats from the 10th to the 19th day of age resulted in reduced testicular growth compared to controls. Body weights and other organ weights were unaffected. Leydig cells were smaller and less numerous, and showed distinct changes in ultrastructural morphology. Results of this study suggest that alpha-fetoprotein permits normal testicular development during postnatal life. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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