Angiotensin II type 2 receptor blocker PD123319 has more beneficial effects than losartan on ischemia/reperfusion injury and oxidative damage in isolated rat heart
| Autor: | Ismail Meral, Savas Ustunova, Cihan Demirci Tansel, Huri Bulut, Aysu Kilic, Ebru Gürel Gürevin, Cansu Usta |
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| Přispěvatelé: | ÜSTÜNOVA, SAVAŞ |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Kilic A. Ustunova S. Usta C. Bulut H. Meral İ. Demirci T. Gurel G. -Angiotensin II type 2 receptor blocker PD123319 has more beneficial effects than losartan on ischemia/reperfusion injury and oxidative damage in isolated rat heart.- Canadian journal of physiology and pharmacology 2019 Physiology Pyridines Ischemia Myocardial Reperfusion Injury Angiotensin II Type 2 Receptor Blockers Pharmacology Receptor Angiotensin Type 2 Losartan Oxidative damage Physiology (medical) Renin–angiotensin system Medicine Animals Rats Wistar Beneficial effects Dose-Response Relationship Drug business.industry Imidazoles General Medicine Rat heart medicine.disease Rats Oxidative Stress Angiotensin II Type-2 Receptor business Reperfusion injury medicine.drug |
| Popis: | Our study aimed to determine the effects of losartan and PD123319 in ischemia–reperfusion (IR) injury in isolated perfused rat heart. The study used 40 male Wistar albino rats that were grouped as Control, IR, and IR treatment groups that received losartan (20 mg/kg), PD123319 (20 mg/kg), and losartan+PD123319. The hearts were attached to Langendorff isolated heart system by employing in situ cannulation method, and cardiodynamic parameters were recorded during the experiment. At the end of experiment, hearts were retained for biochemical analysis and all data were statistically evaluated. A partial recovery of cardiodynamic parameters was observed in all treatment groups. A significant increase in oxidative stress parameters were seen in the IR group, whereas all treatment groups exhibited lower increase. Furthermore, levels of all antioxidant parameters were significantly lower in the IR group, but higher in the treatment groups. Effects on all parameters were much more remarkable in the PD123319 group. Levels of angiotensin II and renin were increased (P < 0.001) with IR application and decreased (P < 0.001) with the treatment of both antagonists. In conclusion, treatment of losartan and PD123319 played a cardioprotective role against IR injury, PD123319 being more effective in this protection. |
| Databáze: | OpenAIRE |
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