Maternal chorioamnionitis and umbilical vein interleukin‐6 levels for identifying early neonatal sepsis
| Autor: | Susan Shen-Schwarz, Jennifer R. Santiago, John C. Smulian, Anthony M. Vintzileos, Yu-Ling Lai, Winston A. Campbell |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Tachycardia
medicine.medical_specialty biology Neonatal sepsis business.industry Obstetrics Obstetrics and Gynecology medicine.disease Chorioamnionitis Umbilical vein Fetal Tachycardia medicine.anatomical_structure Placenta Pediatrics Perinatology and Child Health biology.protein Medicine Leukocytosis medicine.symptom Interleukin 6 business |
| Zdroj: | The Journal of Maternal-Fetal Medicine. 8:88-94 |
| ISSN: | 1520-6661 1057-0802 |
| DOI: | 10.1002/(sici)1520-6661(199905/06)8:3<88::aid-mfm4>3.0.co;2-# |
| Popis: | Objective: The purpose of this study was to determine whether elevated levels of umbilical vein IL-6 would be a better marker for early neonatal sepsis than the clinical signs of maternal chorioamnionitis.Methods: Patients delivering preterm because of spontaneous preterm labor or premature rupture of the membranes were evaluated for clinical signs of chorioamnionitis, which was defined as a temperature of ≥ 100.4°F along with ≥2 of the following: significant maternal tachycardia (≥120 bpm), fetal tachycardia (≥160 bpm), purulent discharge, uterine tenderness, and leukocytosis (WBC ≥ 18,000 cells/mm3). Umbilical vein blood was assayed for interleukin-6. An elevated interleukin-6 level was determined to be 25 pg/mL. Infants were evaluated for evidence of early neonatal sepsis. The abilities of clinical chorioamnionitis and interleukin-6 levels ≥25 pg/mL to predict early neonatal sepsis were compared.Results: There were 28 patients delivering 14 (50%) neonates with evidence for early neonatal sepsis. The in... |
| Databáze: | OpenAIRE |
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