Hemoglobin and Plasma Vitamin C Levels in Patients on Peritoneal Dialysis
| Autor: | Nathan W. Levin, Peter H. Juergensen, Garry J. Handelman, Peter Kotanko, Suxin Wang, Fredric O. Finkelstein, Sally Santacroce, Mark Levine |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Anemia medicine.medical_treatment Ascorbic Acid Gastroenterology Article Peritoneal dialysis Hemoglobins chemistry.chemical_compound Internal medicine medicine Humans In patient Vitamin C business.industry General Medicine Middle Aged medicine.disease Cross-Sectional Studies Endocrinology chemistry Nephrology Female Hemoglobin Dialisis peritoneal business Peritoneal Dialysis Kidney disease |
| Zdroj: | Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 31:74-79 |
| ISSN: | 1718-4304 0896-8608 |
| Popis: | Objective To determine the contribution of vitamin C (Vit C) status in relation to hemoglobin (Hb) levels in patients on long-term peritoneal dialysis (PD). Methods 56 stable PD patients were evaluated in a cross-sectional survey. Plasma samples were collected for Vit C (analyzed by HPLC with electrochemical detection) and high-sensitivity C-reactive protein (hs-CRP) determinations. Clinical records were reviewed for Hb, transferrin saturation (TSAT), ferritin, erythropoietin (EPO) dose, and other clinical parameters. Dietary Vit C intake was evaluated by patient survey and from patient records. Total Vit C removed during PD treatment was measured in 24-hour dialysate collections. Results Patients showed a highly skewed distribution of plasma Vit C levels, with 40% of patients below normal plasma Vit C levels (80 μmol/L). Higher plasma Vit C levels were associated with higher Hb levels (Pearson r = 0.33, p < 0.004). No direct connection between Vit C levels and reported dietary intake could be established. In stepwise multiple regression, plasma Vit C remained significantly associated with Hb ( p = 0.017) but there was no significant association with other variables (dialysis vintage, age, ferritin, TSAT, hs-CRP, residual renal function, and EPO dose). In 9 patients that were evaluated for Vit C in dialysate, plasma Vit C was positively associated (Spearman r = 0.85, p = 0.01) with the amount of Vit C removed during dialysis treatment. Conclusions These data indicate that plasma Vit C is positively associated with higher Hb level. Vit C status could play a major role in helping PD patients to utilize iron for erythropoiesis and achieve a better Hb response during anemia management. |
| Databáze: | OpenAIRE |
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