Physiological effects of low-magnitude electric fields on brain activity: advances from in vitro, in vivo and in silico models
| Autor: | Yves Denoyer, Julien Modolo, Fabrice Wendling, Pascal Benquet |
|---|---|
| Přispěvatelé: | Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie [Rennes] = Neurology [Rennes], CHU Pontchaillou [Rennes], R01NS092760-01A1, National Institutes of Health, H2020-FETOPEN-2014-2015-RIA, Future Emerging Technologies, Modolo, Julien, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Electric fields Brain activity and meditation In silico Biomedical Engineering Medicine (miscellaneous) Bioengineering Stimulation Article Biomaterials 03 medical and health sciences 0302 clinical medicine In vivo Electric field In vitro in vivo [MATH.MATH-RT] Mathematics [math]/Representation Theory [math.RT] transcranial direct current stimulation (tDCS) ComputingMilieux_MISCELLANEOUS Physics computational model [MATH.MATH-RT]Mathematics [math]/Representation Theory [math.RT] in vitro Neurophysiology electrophysiology Electrophysiology in vivo 030104 developmental biology Neuroscience transcranial alternating current stimulation (tACS) 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Biomedical Engineering Current Opinion in Biomedical Engineering, 2018, 8, pp.38-44. ⟨10.1016/j.cobme.2018.09.006⟩ Current Opinion in Biomedical Engineering, Elsevier, 2018, 8, pp.38-44. ⟨10.1016/j.cobme.2018.09.006⟩ |
| ISSN: | 2468-4511 |
| DOI: | 10.1016/j.cobme.2018.09.006⟩ |
| Popis: | While electrical stimulation of brain tissue has been thoroughly investigated over the last decades, ongoing questions remain regarding the neurophysiological effects of low-level electric fields (on the order of 1 V/m) on brain activity. Electric fields at such levels are, for example, induced by transcranial direct/alternating current stimulation (tDCS/tACS). Action potentials can be indeed elicited when applied (supra-threshold) electric fields are in the 10–100 V/m range, while lower (subthreshold) electric fields result in more limited and subtler membrane polarization effects. In this review, we address the question of the mechanisms underlying the immediate effects (also referred to as acute, concurrent or short-term) and the lasting effects (also referred to as long-term or aftereffects) of low-level electric fields on brain tissue. We review recent evidence at the in vitro and in vivo (animal and human) level, and also present mechanistic insights gained from in silico models, which are still few but have received increased attention over the recent past years. We highlight the convergent evidence towards potential mechanisms, and also discuss discrepancies between in vitro studies and human tDCS/tACS studies that require further investigation to bridge the gap between the single-cell and large-scale network level. Possible novel avenues of research are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect