Ethanol extract from Moringa oleifera leaves modulates brown adipose tissue and bone morphogenetic protein 7 in high-fat diet mice
| Autor: | Neni Anggraeni, Mas Rizky A. A. Syamsunarno, Nur Atik, Suhendra Praptama, Fenty Alia, Vanessa Ayu Sumirat |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Vitamin medicine.medical_specialty Normal diet Veterinary medicine bone morphogenetic protein 7 030209 endocrinology & metabolism Biology Body fat percentage SF1-1100 Moringa 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Brown adipose tissue SF600-1100 medicine Potency General Veterinary digestive oral and skin physiology nutritional and metabolic diseases food and beverages moringa oleifera leaves extract brown adipose tissue medicine.disease Obesity Animal culture Bone morphogenetic protein 7 030104 developmental biology medicine.anatomical_structure Endocrinology high-fat diet chemistry Research Article |
| Zdroj: | Veterinary World, Vol 14, Iss 5, Pp 1234-1240 (2021) Veterinary World |
| ISSN: | 2231-0916 0972-8988 |
| Popis: | Background and Aim: Brown adipose tissue's (BAT) ability to increase energy expenditure has become a new focus in obesity research. The amount and activity of BAT are inversely correlated with body-mass index and body fat percentage. Bone morphogenetic protein 7 (BMP7) plays a role in the differentiation and development of BAT, which can be increased by bioactive compounds from several medicinal plants. Moringa oleifera (MO) leaves are rich with vitamin, minerals, and bioactive compounds and have been used for treating obesity-related diseases in the past. The aim of this study was to explore the potency of MO leaf extract (MOLE) to modulate BAT differentiation in mice fed a high-fat diet (HFD). Materials and Methods: Twenty-four, 5-week-old male Deutsche Denken Yoken mice (Mus musculus) were randomly divided into four groups: The normal chow diet group was fed a normal diet, the HFD group was fed a HFD, the HFD+MOLE1, and the HFD+MOLE2 groups were fed HFD and MOLE in a dose of 280 and 560 mg/kg body weight (BW)/day, respectively. The experiment was performed for 7 weeks. At the end of the experiment, histological analysis was performed on the interscapular BAT, and blood was drawn for BMP7 protein levels. Results: After 7 weeks, BAT weight in the HFD group was nearly twice in the weight of the HFD+MOLE1 group (125±13.78 mg vs. 75±13.78 mg; p |
| Databáze: | OpenAIRE |
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