Simple surface sulfonation retards plasticiser migration and impacts upon blood/material contact activation processes
| Autor: | Laurie Shedden, Demetrios M. Stefanou, David C. Horne, Terence Gourlay |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Alkanesulfonates
Male Extracorporeal Circulation Neutrophils Factor XIIa Inflammatory response Cd11b expression Rats Sprague-Dawley Toxicology Andrology chemistry.chemical_compound Blood material Plasticizers Contact activation Diethylhexyl Phthalate Animals Medicine Radiology Nuclear Medicine and imaging Polyvinyl Chloride Inflammation Advanced and Specialized Nursing CD11b Antigen Interleukin-6 business.industry Plasticizer Phthalate General Medicine Flow Cytometry Rats Quaternary Ammonium Compounds chemistry Models Animal Cardiology and Cardiovascular Medicine business Safety Research |
| Zdroj: | Perfusion. 25:31-39 |
| ISSN: | 1477-111X 0267-6591 |
| DOI: | 10.1177/0267659110361997 |
| Popis: | Background. The use of Di-2-ethylhexyl phthalate (DEHP) plasticised polyvinyl chloride (DEHPPPVC) in medical devices persists despite evidence suggesting that DEHP migration can be harmful. Researchers have shown that a simple surface sulfonation process can retard the migration of DEHP, which may reduce the associated inflammatory response. The present study is designed to investigate the effects of surface sulfonation on DEHP migration and blood contact activation using in vitro and rodent models. Methods. The study was carried out in two phases: phase 1, in which the migration rate of DEHP from DEHPPPVC and sulfonated DEHP plasticised PVC (SDEHPPPVC) was measured; phase 2 of the study, in which the materials were incorporated into a rat recirculation biomaterial test model and blood samples taken to assess CD11b expression on neutrophils, IL-6 and Factor XIIa. Results. The initial DEHP concentration washed from the surface after storage was 37.19 ± 1.17 mg/l in the PPVC group and 5.89 ± 0.81 mg/l in the SPPVC group (p Conclusions. The simple sulfonation process significantly retards the migration of DEHP and is associated with the moderation of contact activation processes. |
| Databáze: | OpenAIRE |
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