Strategies for improving the payload of small molecular drugs in polymeric micelles
| Autor: | Xiaolin Liu, Bin Tian, Xiaoguang Tao, Pengqian Tian, Ling Zhang, Dandan Yu, Xing Tang, Tianyang Ren, Jianbo Song, Yanhui Chao, Jingxin Gou, Yu Zhang, Wei Xiao |
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| Rok vydání: | 2017 |
| Předmět: |
Drug
Drug Liberation Polymers media_common.quotation_subject Pharmaceutical Science Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Micelle Drug Delivery Systems Humans Solubility Micelles media_common Drug Carriers Polymeric micelles Chemistry Payload 021001 nanoscience & nanotechnology 0104 chemical sciences Pharmaceutical Preparations Drug delivery 0210 nano-technology Drug carrier Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Journal of Controlled Release. 261:352-366 |
| ISSN: | 0168-3659 |
| Popis: | In the past few years, substantial efforts have been made in the design and preparation of polymeric micelles as novel drug delivery vehicles. Typically, polymeric micelles possess a spherical core-shell structure, with a hydrophobic core and a hydrophilic shell. Consequently, poorly water-soluble drugs can be effectively solubilized within the hydrophobic core, which can significantly boost their drug loading in aqueous media. This leads to new opportunities for some bioactive compounds that have previously been abandoned due to their low aqueous solubility. Even so, the payload of small molecular drugs is still not often satisfactory due to low drug loading and premature release, which makes it difficult to meet the requirements of in vivo studies. This problem has been a major focus in recent years. Following an analysis of the published literature in this field, several strategies towards achieving polymeric micelles with high drug loading and stability are presented in this review, in order to ensure adequate drug levels reach target sites. |
| Databáze: | OpenAIRE |
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