l ‐Asparaginase synergizes with etoposide via the PI3K/Akt/mTOR pathway in Epstein−Barr virus‐positive Burkitt lymphoma
| Autor: | Wei Sang, Dongyun Tu, Meng Zhang, Yuanyuan Qin, Wenjing Yin, Xuguang Song, Cai Sun, Dongmei Yan, Xiangmin Wang, Lingyu Zeng, Zhenyu Li, Kailin Xu, Linyan Xu |
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| Rok vydání: | 2022 |
| Předmět: |
Epstein-Barr Virus Infections
Herpesvirus 4 Human TOR Serine-Threonine Kinases Health Toxicology and Mutagenesis Apoptosis General Medicine Toxicology Burkitt Lymphoma Biochemistry Mice Phosphatidylinositol 3-Kinases Animals Asparaginase Molecular Medicine Proto-Oncogene Proteins c-akt Molecular Biology Etoposide |
| Zdroj: | Journal of Biochemical and Molecular Toxicology. 36 |
| ISSN: | 1099-0461 1095-6670 |
| Popis: | Burkitt lymphoma (BL) is an aggressive Epstein-Barr virus (EBV)-driven B-cell lymphoma characterized by the translocation and rearrangement of the c-Myc proto-oncogene. High-intensity multidrug chemotherapy regimens have a limited effect on the survival of refractory or relapsed BL patients, mainly owing to the high EBV load and drug resistance. l-asparaginase ( l-Asp) and etoposide (VP-16) play a beneficial role in EBV-related lymphoproliferative diseases; however, their roles and mechanisms in BL remain unclear. In this study, we found that VP-16 inhibited BL cell proliferation and arrested the cell cycle at the G |
| Databáze: | OpenAIRE |
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