In-vitro permeation of drugs into porcine hair follicles: is it quantitatively equivalent to permeation into human hair follicles?
| Autor: | Yakov Frum, G.M. Eccleston, Victor M. Meidan |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Swine Skin Absorption Pharmaceutical Science Human skin In Vitro Techniques Biology Models Biological Permeability chemistry.chemical_compound Species Specificity Deoxyadenosine Corticosterone Internal medicine Follicular phase medicine Animals Humans Tissue Distribution Cimetidine Pharmacology integumentary system Molecular mass Permeation Adenosine Endocrinology Pharmaceutical Preparations chemistry Linear Models Biophysics Hair Follicle Hydrophobic and Hydrophilic Interactions medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 60:145-151 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1211/jpp.60.2.0002 |
| Popis: | It is already well-established that the general permeability properties of porcine skin are close to those of human skin. However, very little is known with respect to drug absorption into hair follicles and the similarities if any between the two types of tissue. The aim of this study was to use the skin sandwich system to quantify follicular drug absorption into porcine hair follicles. To our knowledge, this is the first time that the skin sandwich has been extended to porcine tissue. For this purpose, seven different drugs — estradiol, corticosterone, hydrocortisone, aldosterone, cimetidine, deoxyadenosine and adenosine — exhibiting a wide range of log octanol-water partition coefficients (log Ko/w), but comparable molecular weights, were chosen as candidate solutes. The results showed a parabolic profile with maximal follicular contribution occurring at intermediate log Ko/w values. Linear regression analysis indicated that the follicular contributions in porcine skin correlated well with previously published follicular contributions in human skin (r2 = 0.87). The novelty of this research is that we show that porcine tissue is a good surrogate for modelling human skin permeability within the specific context of quantifying drug absorption into hair follicles. |
| Databáze: | OpenAIRE |
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