Serum Pepsinogen as a Predictor for Gastric Cancer Death
| Autor: | Sherry Yueh Hsia Chiu, Jean Ching Yuan Fann, Ming-Shiang Wu, Tony Hsiu Hsi Chen, Tsung-Hsien Chiang, Cheng Ying Liu, Ming Wei Lin, Amy Ming Fang Yen, Chu-Kuang Chou, Sam Li Sheng Chen, Chia-Tung Shun, Yi-Chia Lee, Han-Mo Chiu, Jaw-Town Lin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Taiwan Cohort Studies 03 medical and health sciences 0302 clinical medicine Pepsin Predictive Value of Tests Stomach Neoplasms Pepsinogen A Internal medicine Biomarkers Tumor medicine Humans Cancer death Aged Aged 80 and over Community based biology business.industry Gastroenterology Middle Aged Helicobacter pylori biology.organism_classification digestive system diseases 030220 oncology & carcinogenesis Predictive value of tests biology.protein Female 030211 gastroenterology & hepatology Serum pepsinogen business Cohort study |
| Zdroj: | Journal of Clinical Gastroenterology. 53:e186-e193 |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/mcg.0000000000000992 |
| Popis: | The purpose of this article is to validate the long-term association between initial serum pepsinogen (PG) measurements and subsequent gastric cancer-specific deaths from a long-term longitudinal cohort.Endoscopic surveillance can be effective and efficient in reducing gastric cancer mortality if a biomarker such as serum PG is available to identify high-risk individuals and if the biomarker also is specific to gastric cancer risk.Between 1995 and 1998, a gastric cancer-screening program was conducted in a high-risk population: The first stage involved PG testing, and the second stage involved upper endoscopy. The outcome was gastric cancer death, which was monitored until December 31, 2010; results were expressed as the hazard ratio (HR) and corresponding 95% confidence interval (CI) using the Cox proportional hazards regression model. Other causes of death were used as comparators.Among participants (n=3514) aged ≥30 years, 1682 (47.9%) were screened to determine serum PG levels. After 16 years of follow-up, 14 deaths from gastric cancer were documented. Multivariate analyses adjusted for age, sex, and Helicobacter pylori serological positivity showed that PG-I30 μg/L and PG-I30 μg/L or PG-I/II ratio3 were significantly associated with the risk of gastric cancer death (HR, 3.27; 95% CI, 1.11-9.61 and HR, 3.45; 95% CI, 1.18-10.12, respectively). In contrast, there were no significant associations between PG and other causes of death, including neoplastic and non-neoplastic diseases.This long-term cohort study shows the usefulness of PG measurement as a biomarker that is specific to the risk of gastric cancer death. |
| Databáze: | OpenAIRE |
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