Atypical cyclins: the extended family portrait
| Autor: | Eva Quandt, Josep Clotet, Mariana P.C. Ribeiro |
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| Rok vydání: | 2019 |
| Předmět: |
Subfamily
Ciclo celular Computational biology Canònic Review Cell cycle Cicle cel·lular 03 medical and health sciences Cellular and Molecular Neuroscience Fosforilació 0302 clinical medicine Cyclin-dependent kinase Cyclins Canónico Animals Humans Phosphorylation Molecular Biology Phylogeny 030304 developmental biology Cyclin Sequence (medicine) Pharmacology 0303 health sciences biology Phylogenetic tree Genome Human Extended family Cyclin family Cell Biology Cyclin-Dependent Kinases Canonical Transcripcional Família de ciclines 030220 oncology & carcinogenesis biology.protein Molecular Medicine Familia ciclina Human genome Transcriptional Fosforilación Cell Division |
| Zdroj: | Cellular and Molecular Life Sciences |
| ISSN: | 1420-9071 |
| Popis: | Regulation of cell division is orchestrated by cyclins, which bind and activate their catalytic workmates, the cyclin-dependent kinases (CDKs). Cyclins have been traditionally defined by an oscillating (cyclic) pattern of expression and by the presence of a characteristic “cyclin box” that determines binding to the CDKs. Noteworthy, the Human Genome Sequence Project unveiled the existence of several other proteins containing the “cyclin box” domain. These potential “cyclins” have been named new, orphan or atypical, creating a conundrum in cyclins nomenclature. Moreover, although many years have passed after their discovery, the scarcity of information regarding these possible members of the family has hampered the establishment of criteria for systematization. Here, we discuss the criteria that define cyclins and we propose a classification and nomenclature update based on structural features, interactors, and phylogenetic information. The application of these criteria allows to systematically define, for the first time, the subfamily of atypical cyclins and enables the use of a common nomenclature for this extended family. |
| Databáze: | OpenAIRE |
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