Verapamil accelerates the transition to heart failure in obese, hypertensive, female SHHF/Mcc-fa(cp) rats
| Autor: | J. Hensley, Ruth A. Altschuld, Radin Mj, C. M. Hohl, Hoepf Tm, Sonhee Park, Sylvia A. McCune |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Heart disease Blood Pressure In Vitro Techniques Myosins Internal medicine Rats Inbred SHR Medicine Myocyte Animals Pharmacology Heart Failure Sarcolemma Felodipine business.industry Myocardium Antagonist Brain Heart Organ Size medicine.disease Calcium Channel Blockers Rats Endocrinology Verapamil Heart failure Toxicity Hypertension Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of cardiovascular pharmacology. 29(6) |
| ISSN: | 0160-2446 |
| Popis: | We sought to characterize the effects of the nonselective Ca 2+ channel antagonist, verapamil, and the vascular-selective Ca 2+ channel antagonist, felodipine, on obese, hypertensive, heart failure-prone, female SHHF/Mcc-fa cp rats. Rats were treated for ≤2 months with verapamil (57 mg/kg/day) or felodipine (24 mg/kg/day). Blood pressures were determined at monthly intervals by the tail-cuff method. Heart weights and myosin isoforms were measured at the end of treatment. Direct cardiac effects of verapamil and felodipine were examined in electrically field stimulated, fura2/AM-loaded cardiomyocytes. Both Ca 2+ channel antagonists reduced systolic blood pressures. Verapamil, but not felodipine, increased heart weights and decreased expression of the myosin V i isoform. In older animals, 75% of those treated with verapamil developed end-stage congestive heart failure. Age-matched control and felodipine-treated rats remained healthy. In isolated cardiomyocytes, 10 -9 M verapamil significantly reduced Ca 2+ transient amplitudes but 10 -9 M felodipine did not. Both Ca 2+ channel antagonists reduced blood pressures in obese, hypertensive, female SHHF rats. Verapamil, but not felodipine, produced heart failure in a large number of these animals. Differences between the in vivo effects of the two Ca 2+ channel antagonists may be related to the differing effects on sarcolemmal Ca 2+ influx. |
| Databáze: | OpenAIRE |
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