Infiltrating macrophage count: a significant predictor for the progression and prognosis of oral squamous cell carcinomas in Taiwan
| Autor: | Jeng-Wei Tjiu, Chia-Fang Lu, Chun-Pin Chiang, Chiung-Shing Huang |
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| Rok vydání: | 2009 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Pathology Cell Taiwan Cell Count Metastasis Predictive Value of Tests Risk Factors Internal medicine Carcinoma medicine Humans Neoplasm Invasiveness Survival analysis Aged Neoplasm Staging Retrospective Studies business.industry Incidence Macrophages Mouth Mucosa Cancer Middle Aged medicine.disease Prognosis Immunohistochemistry Survival Analysis Tongue Neoplasms stomatognathic diseases medicine.anatomical_structure Early Diagnosis Otorhinolaryngology Dysplasia Predictive value of tests Carcinoma Squamous Cell Disease Progression Female Mouth Neoplasms Neoplasm Recurrence Local business |
| Zdroj: | Headneck. 32(1) |
| ISSN: | 1097-0347 |
| Popis: | Infiltrating macrophage count (IMC) is found to correlate with the progression and prognosis of many human cancers.This study used immunohistochemistry to measure the IMC (macrophages/high-power field [HPF]) in 92 specimens of oral squamous cell carcinoma (OSCC).A significantly increased IMC was found in OSCCs with larger tumor size, positive lymph node metastasis, more advanced clinical stages, or recurrence (all ps.05). Kaplan-Meier survival analysis found that OSCC patients with IMC196 macrophages/HPF had a significantly shorter disease-free (p = .001, log-rank test) or overall survival (p.001, log-rank test) than OSCC patients with IMC196 macrophages/HPF. Multivariate Cox regression analyses showed that IMC196 macrophages/HPF was an independent predictor for poor disease-free (p = .005) and overall survival of patients with OSCC (p = .015).The IMC can predict the progression and prognosis of OSCCs in Taiwan. |
| Databáze: | OpenAIRE |
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