Predictive approaches for post-therapy PET/CT in patients with extranodal natural killer/T-cell lymphoma
| Autor: | Russell O. Kosik, Liqun Zou, Minggang Su, Jie Liu, Chong Jiang, Li Li, Rong Tian |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Multivariate analysis medicine.medical_treatment Standardized uptake value Lymphoma T-Cell Disease-Free Survival 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging In patient Neoplasm Staging Retrospective Studies PET-CT Chemotherapy business.industry Retrospective cohort study General Medicine Middle Aged Natural killer T cell medicine.disease Lymphoma Killer Cells Natural Treatment Outcome 030220 oncology & carcinogenesis Female business Nuclear medicine |
| Zdroj: | Nuclear Medicine Communications. 38:937-947 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/mnm.0000000000000731 |
| Popis: | PURPOSE The aim of this study was to assess the prognostic capacity of three methods of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT analysis carried out after therapy in patients with extranodal natural killer/T-cell lymphoma (ENKTL). The three methods of PET/CT analysis included the International Harmonization Project (IHP) criteria, the Deauville five-point scale (5-PS), and standardized uptake value (SUV)-based assessment. PATIENTS AND METHODS Fifty-nine patients diagnosed with ENKTL were enrolled. Each patient underwent three F-FDG PET/CT scans: (i) baseline, (ii) after two to four cycles of chemotherapy (early response assessment), and (iii) at the end of treatment (evaluation of the final response). Post-therapy F-FDG PET/CT results were determined on the basis of IHP criteria, 5-PS, and change in the maximum F-FDG uptake (ΔSUVmax). IHP criteria, 5-PS, and ΔSUVmax were then examined for their ability to predict progression-free survival (PFS) and overall survival (OS). RESULTS Over a median follow-up of 25 months, 5-PS and ΔSUVmax were significant predictors of PFS and OS. After multivariate analysis, 5-PS could predict PFS (P=0.008) and OS (P=0.002) independently. ΔSUVmax was found to be an independent predictor of PFS (P=0.019), but not OS, and had a lower accuracy and positive predictive value than 5-PS. CONCLUSION Post-therapy PET/CT analysis using the 5-PS is more able to predict survival than analysis with IHP or [INCREMENT]SUVmax in ENKTL patients. |
| Databáze: | OpenAIRE |
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