Time-kill kinetic studies of ampicillin/sulbactam for β-Lactamase-producing enterococci
| Autor: | Patricia A. Farrel, Marcus J. Zervos, Jan E. Patterson |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Microbiology (medical)
biology Aminoglycoside Drug Synergism Ampicillin/sulbactam Microbial Sensitivity Tests General Medicine biochemical phenomena metabolism and nutrition Antimicrobial biology.organism_classification Streptococcaceae beta-Lactamases Enterococcus faecalis Microbiology Kinetics Infectious Diseases Sulbactam Enterococcus medicine Ampicillin Drug Therapy Combination Bacteria Antibacterial agent medicine.drug |
| Zdroj: | Diagnostic Microbiology and Infectious Disease. 14:495-499 |
| ISSN: | 0732-8893 |
| Popis: | beta-Lactamase-producing (Bla+) enterococci have now been reported from several geographic areas. Most of these strains also demonstrate high-level aminoglycoside resistance, making therapy of serious infections due to Bla+ enterococci difficult. Using time-kill kinetic studies, we evaluated the activity of ampicillin-sulbactam (Am/SB) against five clinical Bla+ Enterococcus faecalis isolates from three geographically distinct areas. Am at fourfold minimum inhibitory concentrations (MIC) concentrations did not achieve bactericidal activity as determined by time-kill kinetic studies. Am/SB achieved 99.9% reduction in growth at 24 hr at twofold MIC concentrations without an aminoglycoside in four of five strains. SB alone had little independent activity against any of the strains, but synergy of killing was achieved in all five strains with a combination of Am + SB. No synergy was shown in a Bla- control strain. Am/SB may be useful for serious infections due to Bla+ enterococci. |
| Databáze: | OpenAIRE |
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