Does mTORC1 inhibit autophagy at dual stages?
| Autor: | Tamilselvan Jayavelu, Anand Ramaian Santhaseela |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Chemistry Autophagy Late stage mTORC1 Mechanistic Target of Rapamycin Complex 1 General Biochemistry Genetics and Molecular Biology Cell biology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Biological significance Lysosome medicine Humans biological phenomena cell phenomena and immunity Signal transduction Lysosomes 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | BioEssays. 43:2000187 |
| ISSN: | 1521-1878 0265-9247 |
| DOI: | 10.1002/bies.202000187 |
| Popis: | Extensive studies have attributed the lysosomal localization of the mechanistic target of rapamycin complex 1 (mTORC1) during its activation. However, the exact biological significance of this lysosomal localization of mTORC1 remains ill-defined. Interestingly, findings have shown that localization of the lysosome itself is altered under conditions influencing mTORC1 activity. In this perspective, we hypothesize that the localization of mTORC1 and lysosome could be interconnected in a way that manifests regulation of autophagy that is already under progression at the time of mTORC1 activation. This provides a new possibility for autophagy regulation whose complete mechanistic insights remain to be determined. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text