| Popis: |
Ivermectin (IVM) is a semi-synthetic substance derived from avermectin, which is naturally produced by Streptomyces avermitilis. It is very effective in the control of endo- and ecto-parasites such as gastrointestinal nematodes, lice, and mites in livestock. In the present study an attempt has been made to prepare fast dissolving tablets of Ivermectin, Xanthan gum, Sod. Alginate, Sodium starch glycolate used in the level of addition to increase the rate of drug release from dosage form to increase the dissolution rate. Direct Compression method was used to formulate the tablets. The prepared Tablets were further evaluated for Hardness, Friability, disintegration time, and uniformity of drug content, and In-vitro Release Studies. Percentage assay of different formulation was determined by U.V. vis Spectroscopy. The percentage assay of different formulation was in range of 98.45±0.23 to 99.75±0.24%. The maximum percentage assay (99.75±0.24%) and less disintegration time were found to be formulation F3 in Fast dissolving tablets. The optimized formulation of batch F3 subjected to further In vitro drug release. Overall the results of the dissolution rate studies indicated greater dissolution rate of Ivermectin from fast dissolving tablets. Key words: Ivermectin, Fast dissolving tablets, Natural Polymers, formulation and evaluation |
