Decreased testosterone secretion index and free testosterone level with multiple symptoms for late-onset hypogonadism identification: a nationwide multicenter study with 5980 aging males in China
| Autor: | Liandong Zuo, Ying Qi, Huangtao Guan, Xue-jun Shang, Shan-Jie Zhou, Yaoping Chen, Xing-Rong Qing, Wenpei Xiang, Guangan Mei, Yiqun Gu, Chengliang Xiong, Xiangbin Kong, Lin-Guo Tang, Wei Xia, Weixiong Wu, Chang-Chun Wan, Bao-Jin Hao, Na Yu, Honggang Li, Yuanzhong Zhou, Yi-Hong Yang, Xubo Shen, Huiping Zhang |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male China Aging medicine.medical_specialty Libido Late onset Burnout Psychological late-onset hypogonadism Pathogenesis Decreased Testosterone Secretion Asian People Testosterone deficiency Sex Hormone-Binding Globulin Internal medicine medicine Humans Caucasian population Fatigue Aged aging male Free testosterone business.industry Hypogonadism Testosterone (patch) Cell Biology Luteinizing Hormone Middle Aged Irritable Mood testosterone secretion index Sexual Dysfunction Physiological Endocrinology Multicenter study testosterone business Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Late-onset hypogonadism (LOH) is a syndrome in middle-aged and elderly men caused by age-related testosterone deficiency. Age-related change of total testosterone (TT) of Asian males is different from Caucasian population, suggesting difference for LOH identification in Asians. A nationwide cross-sectional study involving six centers in China was conducted. Totally 6296 men aged 40-79 were recruited. After exclusions 5980 men were left for analyses. The serum TT level, was neither decreased with aging nor correlated with most hypogonadal symptoms. Instead, ten hypogonadal symptoms were found to be significantly correlated with free testosterone and testosterone secretion index, thus were chosen to form a concise scale. Further analysis identified a level of free testosterone |
| Databáze: | OpenAIRE |
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