Inducing Intermediates in Biotransformation of Natural Polyacetylene and A Novel Spiro-γ-Lactone from Red Ginseng by Solid Co-Culture of Two Gut Chaetomium globosum and The Potential Bioactivity Modification by Oxidative Metabolism

Autor:	Xue-Yin Wang, Shuang Yang, Ming Hu, Zhong-Tao Ding, Bang-Yan Wang, Xue-Qiong Yang, Ting-Ting Xu, Ya-Bin Yang, Chen-Hao Zhu
Rok vydání:	2020
Předmět:	0106 biological sciences chaetomium globosum Metabolite Pharmaceutical Science 01 natural sciences Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound Ginseng lcsh:Organic chemistry Biotransformation oxidative metabolism 010608 biotechnology Drug Discovery detoxification Physical and Theoretical Chemistry 030304 developmental biology chemistry.chemical_classification 0303 health sciences Chaetomium globosum Organic Chemistry food and beverages Metabolism polyacetylene Metabolic pathway Biochemistry chemistry Chemistry (miscellaneous) Molecular Medicine Fermentation fermented red ginseng Lactone
Zdroj:	Molecules, Vol 25, Iss 5, p 1216 (2020)
ISSN:	1420-3049
DOI:	10.3390/molecules25051216
Popis:	The ω-hydroxyl-panaxytriol (1) and ω-hydroxyl-dihydropanaxytriol (2)—are rare examples of polyacetylene metabolism by microbial transformation, and these new metabolites (1, 2) from fermented red ginseng (FRG) by solid co-culture induction of two Chaetomium globosum should be the intermediates of biotransformation of panaxylactone (metabolite A). The metabolic pathway of panaxylactone was also exhibited. The ingredients of red ginseng (RG) also induced the production of rare 6/5/5 tricyclic ring spiro-γ-lactone skeleton (3). The ω-hydroxylation of new intermediates (1, 2) decreases cytotoxicity and antifungal activity against C. globosum compared with that of its bioprecursor panaxytriol. Additionally, compounds 1 and 2 indicated obvious inhibition against nitric oxide (NO) production, with ratios of 44.80 ± 1.37 and 23.10 ± 1.00% at 50 μM. 1 has an equivalent inhibition of NO production compared with the positive drug. So, the microbial biotransformation that occurred in FRG fermented by gut C. globosum can change the original bioactivity of polyacetylene, which gave a basis about the metabolic modification of red ginseng by intestinal fungus fermentation.
Databáze:	OpenAIRE
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