Modulation of the Ca2+- or Pb2+-activated K+-selective channels in human red cells. I. Effects of propranolol

Autor:	R. Fehlau, G.F. Fuhrmann, H.J. Keim, Wolfgang Schwarz
Rok vydání:	1989
Předmět:	Potassium Channels Biophysics Propranolol Biochemistry chemistry.chemical_compound medicine Humans Patch clamp Calcimycin HEPES Chemistry Sulfates Erythrocyte Membrane Sodium Conductance Cell Biology Hyperpolarization (biology) Potassium channel MOPS EGTA Lead Potassium Calcium medicine.drug
Zdroj:	Biochimica et biophysica acta. 978(1)
ISSN:	0006-3002
Popis:	To study the effect of propranolol on the Ca2+- or Pb2+-activated K+ permeability in human erythrocytes, K+ effluxes were compared with single-channel currents. The results demonstrate that propranolol has a twofold effect: (1) it renders the channel protein more sensitive to Ca2+ or Pb2+; and (2) it simultaneously inhibits channel activity and slightly reduces single-channel conductance. The number of active channels is not affected.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1c521a48ce3c85f926db59228b611f https://pubmed.ncbi.nlm.nih.gov/2492431 Zobrazit plný text záznamu