Susceptibilities of Mycoplasma hominis, Mycoplasma pneumoniae, and Ureaplasma urealyticum to a new quinolone, OPC 17116
| Autor: | George E. Kenny, Frank D. Cartwright |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Mycoplasma pneumoniae
Ofloxacin Mycoplasmataceae Mycoplasma hominis Microbial Sensitivity Tests Quinolones medicine.disease_cause Piperazines Microbiology Mycoplasma Anti-Infective Agents medicine Pharmacology (medical) heterocyclic compounds Antibacterial agent Pharmacology biology Temafloxacin biochemical phenomena metabolism and nutrition biology.organism_classification bacterial infections and mycoses Virology Infectious Diseases Sparfloxacin Ureaplasma urealyticum medicine.drug Research Article Fluoroquinolones |
| Popis: | The susceptibilities of human mycoplasmas to OPC 17116 (Otsuka America Pharmaceutical, Inc., Rockville, Md.) and temafloxacin (Abbott Laboratories, Chicago, Ill.) were determined by the agar dilution method and were compared with those to sparfloxacin and ofloxacin. The MICs of OPC 17116 for 90% of Mycoplasma pneumoniae (0.25 microgram/ml) and Mycoplasma hominis (0.125 micrograms/ml) isolates tested were closely similar to those of sparfloxacin and were four- to eightfold greater than those of ofloxacin. Temafloxacin was two- to fourfold more active than ofloxacin. Ureaplasma urealyticum was less susceptible; the MICs of OPC 17116 and temafloxacin for 90% of isolates tested were 2 and 4.0 micrograms/ml, respectively. |
| Databáze: | OpenAIRE |
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