Short Report: Asymptomatic Zika virus infections with low viral loads not likely to establish transmission in New Orleans Aedes populations

Autor: Christine E S Walsh, Matthew J Ward, Rebecca C. Christofferson, Joshua Yukich, Brendan H Carter, Dawn M. Wesson
Rok vydání: 2020
Předmět:
RNA viruses
Male
0301 basic medicine
Viral Diseases
Physiology
viruses
Disease Vectors
Pathology and Laboratory Medicine
Virus Replication
Mosquitoes
Zika virus
Serology
0302 clinical medicine
Aedes
Medicine and Health Sciences
Multidisciplinary
Zika Virus Infection
Eukaryota
New Orleans
virus diseases
Viral Load
Body Fluids
Insects
Autochthonous Transmission
Infectious Diseases
Blood
Medical Microbiology
Viral Pathogens
Viruses
Medicine
Female
Pathogens
Viral Vectors
Anatomy
Viral load
Wolbachia
Research Article
Aedes albopictus
Post exposure
Arthropoda
Science
030231 tropical medicine
Mosquito Vectors
Aedes aegypti
Aedes Aegypti
Biology
Microbiology
03 medical and health sciences
Virology
Animals
Humans
Serologic Tests
Viremia
Saliva
Microbial Pathogens
Biology and life sciences
Flaviviruses
Bacteria
Extramural
fungi
Organisms
Zika Virus
biology.organism_classification
Invertebrates
Insect Vectors
Species Interactions
030104 developmental biology
Viral Transmission and Infection
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0233309 (2020)
ISSN: 1932-6203
Popis: Aedes aegypti and Aedes albopictus are both vectors of Zika virus and both are endemic to the New Orleans Metropolitan area. Fortunately, to date there has been no known autochthonous transmission of Zika virus in New Orleans. No studies of the vector competence of local populations of Ae. aegypti and Ae. albopictus for Zika virus transmission have been conducted. To determine if New Orleans Ae. aegypti and Ae. albopictus mosquitoes are competent for Zika virus, mosquitoes were reared to generation F3 from eggs collected in New Orleans during the 2018 mosquito season. Adults were fed an infectious blood meal and kept for 15 days in an environmental chamber. Transmission assays were conducted at 4, 10, and 15 days post exposure and RT-PCR was run on bodies and saliva to detect the presence of Zika virus RNA. We observed remarkably low susceptibility of both Ae. aegypti and Ae. albopictus from New Orleans to a Zika strain from Panama after oral challenge. These results suggest a limited risk of Zika virus transmission should it be introduced to the New Orleans area, and may partially explain why no transmission was detected in Louisiana during the 2016 epidemic in the Americas, despite multiple known travel associated introductions to New Orleans. Despite these results these mosquito populations are known to be competent vectors for some other mosquito-borne viruses and control measures should not be relaxed.
Databáze: OpenAIRE
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