Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study

Autor: Nowee, M.E., Voncken, F.E.M., Kotte, A.N.T.J., Goense, L., Rossum, P.S.N. van, Lier, A.L.H.M.W. van, Heijmink, S.W., Aleman, B.M.P., Nijkamp, J., Meijer, G.J., Lips, I.M., Braam, P.M., Buijsen, J., Ceha, H.M., Dewit, L., Franssen, J.H., Gestel, K. van, Grootenboers, D.A.R.H., Intven, M., Jansen, E.P.M., Kerkmeijer, L.G.W., Mul, V.E., Muller, K., Neelis, K.J., Oppedijk, V., Rozema, T., Spruit, P.H., Dutch Natl Platform Radiotherapy
Jazyk: angličtina
Rok vydání: 2019
Předmět:
CIgen
generalized conformity index
Gross tumour volume
medicine.medical_treatment
R895-920
GTV delineation
Computed tomography
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
Medical physics. Medical radiology. Nuclear medicine
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
0302 clinical medicine
medicine
Journal Article
Perpendicular distance
Radiology
Nuclear Medicine and imaging
SUV
standardized uptake volume
RC254-282
Positron Emission Tomography-Computed Tomography
dCRT
definitive chemoradiation
medicine.diagnostic_test
business.industry
Oesophageal cancer
nCR
neoadjuvant chemoradiation
GTV
gross tumour volume
Cancer
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Chemoradiotherapy
medicine.disease
FDG-PET/CT
Conformity index
Radiation therapy
Oncology
EGJ
oesophageal-gastric junction
Radiology Nuclear Medicine and imaging
030220 oncology & carcinogenesis
AJCC
American Joint Committee on Cancer
Interobserver variability
SD
standard deviation
business
Nuclear medicine
Zdroj: CLINICAL & TRANSLATIONAL ONCOLOGY, 14, 33-39
Aarhus University
Clinical and Translational Radiation Oncology, 14, pp. 33-9
Clinical and Translational Radiation Oncology, Vol 14, Iss, Pp 33-39 (2019)
Clinical and translational radiation oncology, 14, 33
Nowee, M E, Voncken, F E M, Kotte, A N T J, Goense, L, van Rossum, P S N, van Lier, A L H M W, Heijmink, S W, Aleman, B M P, Nijkamp, J, Meijer, G J & Lips, I M 2019, ' Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study ', Clin Transl Radiat Oncol, vol. 14, pp. 33-39 .
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, 14, 33-9
ISSN: 2405-6308
Popis: Highlights • Interobserver variability in delineation of the oesophageal GTV can be considerable. • Delineation variation is mainly located at the cranial and caudal border. • PET significantly influences the delineated GTV in oesophageal cancer. • The impact of PET to CT on observer variation of the GTV is limited. • Accurate GTV delineation is essential for results of radiation boost-strategies.
Background and purpose Accurate delineation of the primary tumour is vital to the success of radiotherapy and even more important for successful boost strategies, aiming for improved local control in oesophageal cancer patients. Therefore, the aim was to assess delineation variability of the gross tumour volume (GTV) between CT and combined PET-CT in oesophageal cancer patients in a multi-institutional study. Materials and methods Twenty observers from 14 institutes delineated the primary tumour of 6 cases on CT and PET-CT fusion. The delineated volumes, generalized conformity index (CIgen) and standard deviation (SD) in position of the most cranial/caudal slice over the observers were evaluated. For the central delineated region, perpendicular distance between median surface GTV and each individual GTV was evaluated as in-slice SD. Results After addition of PET, mean GTVs were significantly smaller in 3 cases and larger in 1 case. No difference in CIgen was observed (average 0.67 on CT, 0.69 on PET-CT). On CT cranial-caudal delineation variation ranged between 0.2 and 1.5 cm SD versus 0.2 and 1.3 cm SD on PET-CT. After addition of PET, the cranial and caudal variation was significantly reduced in 1 and 2 cases, respectively. The in-slice SD was on average 0.16 cm in both phases. Conclusion In some cases considerable GTV delineation variability was observed at the cranial-caudal border. PET significantly influenced the delineated volume in four out of six cases, however its impact on observer variation was limited.
Databáze: OpenAIRE
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